David Maxwell Rothwarf

US Patent:

6689575, Feb 10, 2004

Filed:

Feb 28, 2001

Appl. No.:

09/796872

Inventors:

Michael Karin - San Diego CA
Joseph A. DiDonato - Westlake OH
David M. Rothwarf - La Jolla CA
Makio Hayakawa - Tokyo, JP
Ebrahim Zandi - Duarte CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 148

US Classification:

435 15, 435194, 435 71, 435325, 4352523, 4353201, 530350

Abstract:

The present invention provides an isolated nucleic acid molecules encoding I B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I B) that inhibits the activity of the NF- B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies. The invention further provides methods of substantially purifying an IKK complex, methods of identifying an agent that can alter the association of an IKK complex or an IKK catalytic subunit with a second protein, and methods of identifying proteins that can interact with an IKK complex or an IKK catalytic subunit.

US Patent:

7015047, Mar 21, 2006

Filed:

Mar 21, 2002

Appl. No.:

10/104571

Inventors:

Mingxian Huang - San Diego CA, US
Lei Wu - San Diego CA, US
Xiaobo Wang - San Diego CA, US
Junquan Xu - San Diego CA, US
Guo Liang Tao - San Diego CA, US
David M. Rothwarf - La Jolla CA, US

Assignee:

Aviva Biosciences Corporation - San Diego CA

International Classification:

G01N 33/553

US Classification:

436526, 435 71, 435 6

Abstract:

This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.

US Patent:

7189832, Mar 13, 2007

Filed:

Aug 20, 1999

Appl. No.:

09/377795

Inventors:

Michael Karin - La Jolla CA, US
David M. Rothwarf - La Jolla CA, US
Ebrahim Zandi - Duarte CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07H 21/04
C07K 14/00

US Classification:

536 231, 536 245, 530350

Abstract:

The present invention provides a novel essential regulatory subunit of the IκB kinase (IKK) complex, IKK-γ. The isolated IKK-γ subunit of the invention has substantially the same amino acid sequence as SEQ ID NO: 2 shown in FIG.

US Patent:

7314615, Jan 1, 2008

Filed:

Dec 17, 2003

Appl. No.:

10/739821

Inventors:

Michael Karin - San Diego CA, US
Joseph A. DiDonato - Westlake OH, US
David M. Rothwarf - La Jolla CA, US
Makio Hayakawa - Tokyo, JP
Ebrahim Zandi - Duarte CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A01N 65/00
G01N 33/53
C12P 21/04
C12N 5/06
C07K 16/00

US Classification:

424 931, 424 937, 435 71, 435 696, 435326, 5303871, 5303881

Abstract:

The present invention provides an isolated nucleic acid molecules encoding IκB kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (IκB) that inhibits the activity of the NF-κB transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an IκB protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies. The invention further provides methods of substantially purifying an IKK complex, methods of identifying an agent that can alter the association of an IKK complex or an IKK catalytic subunit with a second protein, and methods of identifying proteins that can interact with an IKK complex or an IKK catalytic subunit.

US Patent:

7718419, May 18, 2010

Filed:

Aug 20, 2007

Appl. No.:

11/841935

Inventors:

Lei Wu - San Diego CA, US
Xiaobo Wang - San Diego CA, US
Guoliang Tao - San Diego CA, US
Junquan Xu - San Diego CA, US
Jing Cheng - Beijing, CN
Mingxian Huang - San Diego CA, US
Baoquan Sun - Shangdong Province, CN
Wei Shao - Biejing, CN
Litian Liu - Beijing, CN
Depu Chen - Beijing, CN
David M. Rothwarf - La Jolla CA, US
Weiping Yang - San Diego CA, US

Assignee:

Aviva Biosciences Corporation - San Diego CA

International Classification:

C12M 1/34
G01N 33/553

US Classification:

4352872

Abstract:

This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.

US Patent:

7723029, May 25, 2010

Filed:

Jun 15, 2005

Appl. No.:

11/153825

Inventors:

Mingxian Huang - San Diego CA, US
David Rothwarf - La Jolla CA, US
Jia Xu - San Diego CA, US
Xiaobo Wang - San Diego CA, US
Lei Wu - San Diego CA, US
Antonio Guia - San Diego CA, US

Assignee:

Aviva Biosciences Corporation - San Diego CA

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention recognizes that the determination of an ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and methods of use that allow for the direct analysis of ion transport functions or properties using microfabricated structures that can allow for automated detection of one or more ion transport functions or properties. These biochips and methods of use thereof are particularly appropriate for automating the detection of ion transport functions or properties, particularly for screening purposes.

US Patent:

7776543, Aug 17, 2010

Filed:

Aug 7, 2001

Appl. No.:

09/924428

Inventors:

Lei Wu - San Diego CA, US
Xiaobo Wang - San Diego CA, US
Guoliang Tao - San Diego CA, US
Junquan Xu - San Diego CA, US
Jing Cheng - Beijing, CN
Mingxiang Huang - San Diego CA, US
Baoquan Sun - Shangdong Province, CN
Wei Shao - Nanjing, CN
Litian Liu - Beijing, CN
Depu Chen - Beijing, CN
David M. Rothwarf - La Jolla CA, US
Weiping Yang - San Diego CA, US

Assignee:

Aviva Biosciences Corporation - San Diego CA
Tsinghua University - Beijing
CAPTIALBIO Corporation - Beijing

International Classification:

G01N 33/53

US Classification:

435 71, 422 56, 422 57, 422 8205

Abstract:

This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.

US Patent:

7811768, Oct 12, 2010

Filed:

Aug 7, 2001

Appl. No.:

09/924428

Inventors:

Lei Wu - San Diego CA, US
Xiaobo Wang - San Diego CA, US
Guoliang Tao - San Diego CA, US
Junquan Xu - San Diego CA, US
Jing Cheng - Beijing, CN
Mingxiang Huang - San Diego CA, US
Baoquan Sun - Shangdong Province, CN
Wei Shao - Nanjing, CN
Litian Liu - Beijing, CN
Depu Chen - Beijing, CN
David M. Rothwarf - La Jolla CA, US
Weiping Yang - San Diego CA, US

Assignee:

Aviva Biosciences Corporation - San Diego CA
Tsinghua University - Beijing
CAPTIALBIO Corporation - Beijing

International Classification:

G01N 33/53

US Classification:

435 71, 422 56, 422 57, 422 8205

Abstract:

This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.