Jianzhong Huang - King of Prussia PA 19406-0939 Xinhe Jiang - King of Prussia PA 19406-0939 David Payne - King of Prussia PA 19406-0939 Stephanie Van Horn - King of Prussia PA 19406-0939 Nicola Gail Wallis - King of Prussia PA 19406-0939
The invention provides MurA polypeptides and polynucleotides encoding MurA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurA polypeptides to screen for antibacterial compounds.
Christine Debouck - Wayne PA Daniel Robert Gentry - Pottstown PA Deborah Dee Jaworski - West Chester PA John Timothy Londsdale - Exton PA Jeffrey L Mooney - Limerick PA David John Payne - Phoenixville PA Stewart Campbell Pearson - Berwyn PA Lisa Kathleen Schilling - Newtown PA Glenn Scott Van Aller - Reading PA Min Wang - Blue Bell PA Yi Yi Zhong - Collegeville PA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C12N 910
US Classification:
435193, 4353201, 435325, 4352523, 536 232
Abstract:
The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.
Methods Of Screening For Fabk Antagonists And Agonists
The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing FabK polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
Martin Brandt - North Wales PA, US Paul M. Keller - West Chester PA, US Arunbhai H. Patel - Colonial Beach VA, US David J. Payne - Phoenixville PA, US Shannon L. Reed - Norristown PA, US Mark A. Seefeld - Collegeville PA, US David G. Tew - Harlow, GB Nicola G. Wallis - Wayne PA, US Joshua M. West - Allentown PA, US
Assignee:
Affinium Pharmaceuticals, Inc. - Toronto
International Classification:
A61K 39/00 A01N 37/18
US Classification:
4241841, 514 2
Abstract:
The invention provides methods for using agonists and antagonists of FabK polypeptides, particularly to modulate the metabolism of bacteria or to treat bacterial infection.
The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabK polypeptides to screen for antibacterial compounds.
Methods Using The Srp Polynucleotides And Polypeptides And Compounds Modulating Their Activity
Christy Cheever - Strafford PA, US Douglas Fecteau - Conshohocken PA, US Hu Li - Eagleville PA, US David Payne - Phoenixville PA, US Angela Steel - Chester Springs PA, US Lei Wang - Conshohocken PA, US
International Classification:
A61K031/00 C07K014/315
US Classification:
514/001000, 530/350000
Abstract:
The invention provides methods for RNA screening for antimicrobial compounds using ffh polypeptides and DNA (RNA) encoding ffh polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ffh polypeptides to screen for antibacterial compounds.
Deborah Jaworski - Collegeville PA, US David Payne - Collegeville PA, US Courtney Slater-Radosti - Collegeville PA, US Kang Yan - Collegeville PA, US
International Classification:
C12N009/00 A61K038/43
US Classification:
424/094100, 435/183000
Abstract:
A method of modulating the activity of a DXR reductoisomerase enzyme, involving contacting a DXR reductoisomerase enzyme with a compound that inhibits non-mevalonate isoprenoid biosynthesis by lowering or preventing the biosynthesis of either menaquinone or ubiquinone. Pharmaceutical compositions containing such compounds may be used to treat infections. Also provided are methods for utilizing DXR polypeptides and polynucleotides to screen for antibacterial compounds.
Dr. Payne graduated from the Wayne State University School of Medicine in 1974. He works in Cadillac, MI and specializes in Pulmonary Disease and Internal Medicine. Dr. Payne is affiliated with Munson Healthcare Hospital.
Orthopaedic Surgery Of Spine, Orthopedic Sports Medicine
Work:
Industrial Orthopedics Spine & Sports Medicine 1530 E 1 St STE 216, Santa Ana, CA 92701 714 479-0840 (phone), 714 836-5327 (fax)
Education:
Medical School Wayne State University School of Medicine Graduated: 1985
Procedures:
Shoulder Arthroscopy
Conditions:
Intervertebral Disc Degeneration Osteoarthritis Rotator Cuff Syndrome and Allied Disorders Spinal Stenosis Fractures, Dislocations, Derangement, and Sprains
Languages:
English Spanish
Description:
Dr. Payne graduated from the Wayne State University School of Medicine in 1985. He works in Santa Ana, CA and specializes in Orthopaedic Surgery Of Spine and Orthopedic Sports Medicine. Dr. Payne is affiliated with College Medical Center and Gardens Regional Hospital & Medical Center.
Midtown Sports Imaging 115 E 61 St STE 7A, New York, NY 10065 212 888-9599 (phone), 212 888-9699 (fax)
Education:
Medical School Howard University College of Medicine Graduated: 1980
Languages:
English Spanish
Description:
Dr. Payne graduated from the Howard University College of Medicine in 1980. He works in New York, NY and specializes in Diagnostic Radiology and Neuroradiology. Dr. Payne is affiliated with Health Alliance Marys Avenue Campus.
By Riverons description of lifting and violently throwing a player to the ground, then landing with all or most of his body weight on the player, David Payne shouldve been flagged for his hit on Rodgers. By the method in which theyve called RTP so far, it was a penalty. By the eye of anybod
Date: Sep 24, 2018
Category: Headlines
Source: Google
Madeleine has gone... We've let her down, Kate McCann cried
In her book Kate paints a picture of family bliss during this time, as a happy but tired Madeleine is read stories and chats about all the fun she had been having. David Payne knocks on the door of apartment 5a at the suggestion of Gerry, to see if Kate needed a hand looking after the children. Dav
opitar owned his shortcomings. Though he was looking to the future, he couldn't help but think about his long relationship with Sutter and Lombardi. Kopitar and some of his teammates went to Lombardi's house Monday after they found out about the firings. (Assistant coach David Payne was let go Tuesday).
Date: Apr 11, 2017
Category: Sports
Source: Google
Six million borrowers are behind on car payments. Housing bubble redux?
"On the one side, folks remember the housing subprime crisis and worry about something similar happening in autos," says David Payne, an economist at Kiplinger, a personal finance and business forecasting website. "On the other side, the rise in subprime lending will lead to higher defaults, but the
Date: Dec 01, 2016
Category: Business
Source: Google
Strong holiday sales so far bode well for the economy
Everything dealing with the consumer seems to be very positive, notes David Payne, an economist at Kiplinger, a personal finance and business forecasting website. This includes strong job growth, a low unemployment rate, and incomes that are finally starting to rise.
Date: Nov 30, 2016
Category: Business
Source: Google
Antibiotic-Resistant Gonorrhea Is A Looming Threat
Discovering new antibiotics is difficult and costly, and there isnt much incentive for drug companies to invest in it, according to David Payne, head of the Antibacterial Discovery Performance Unit at GlaxoSmithKline.
Date: Jul 19, 2016
Category: Health
Source: Google
New Incentives Needed to Develop Antibiotics to Fight Superbugs
The return on investment based on the current commercial model is not really commensurate with the amount of effort you have to put into it, said David Payne, who heads the GlaxoSmithKline PLC GSK antibiotics drug group.
"I believe that we're beyond the point in the campaign where we feel we can unify. Theres been too much bad blood that's been created," said GOP strategist David Payne, who said he would like to see Cruz win the nomination before the convention.
Berwyn Heights, MD Cheverly, MD Kingston, NJ New Brunswick, NJ Aiken, SC Syracuse, NY Daytona Beach, FL Fayetteville, NC Ithaca, NY Somerset County, NJ Barnwell, SC Charlottesville, VA
Work:
Disabled - Veteran (2008)
Education:
University of Maryland University College - Business Administration, Franklin Township High School
Bragging Rights:
Have 2 great kids:-)
David Payne
Work:
Henkel - Data Center Service Manager Henkel - Global Vendor Manager (2009-2011) Henkel - ITIL Service Management (2007-2009) Henkel - Service Engineer (2006-2007)
Education:
WGU - Masters Business Administration, ECPI, UNCG, Chapel Hill High
David Payne
Work:
Gannett Company - Chief Digital Officer (2011) ShortTail Media - CEO (2008-2011) CNN - General Manager (2004-2008)
Education:
Duke University School of Law, Duke University
Relationship:
Married
David Payne
Work:
Owner Apynes roofing part owner
Education:
Belden
About:
I'm a retirerd roofng contractorlive in tupelo, ms.have 2 kids 6 grand kids and 4 great grands
Bragging Rights:
Went to belden high school
David Payne
Education:
Ohio State University - Communications
David Payne
Education:
University of Michigan, Harvard Business School
David Payne
Work:
Ficcadenti Waggoner and Castle - Project Engineer (6)