David J Morgans

US Patent:

20010044440, Nov 22, 2001

Filed:

Feb 23, 2001

Appl. No.:

09/792876

Inventors:

David Morgans - Los Altos CA, US
Silke Thode - Los Gatos CA, US
Dongxu Sun - Cupertino CA, US

International Classification:

C07D211/68
A61K031/513
A61K031/506
A61K031/4545
A61K031/44

US Classification:

514/256000, 514/269000, 514/275000, 514/318000, 514/345000, 514/349000, 544/315000, 544/330000, 546/193000, 546/290000, 546/304000

Abstract:

Compounds of formula I are effective modulators of p38 MAP kinase. wherein Ris H, lower alkyl, or OR, where Ris aryl, heterocyclyl, acyl, N—R-4-piperidinyl, N—R-4-piperidinylmethyl, or N—R-4-pipelidinylethyl, where aryl and heterocyclyl are substituted with 1-3 Rsubstituents selected from the group consisting of H, lower alkyl, lower alkenyl, OH, NO, NH, halo, trihalomethyl, —CN, SH, SO, SO, SOH, —OR, —COR, —COOR, —CONHR, —OCOR, and —NCOR, where R is lower alkyl; Ris H or lower alkyl; Ris aryl substituted with 1-3 Rsubstituents; Ris H, lower alkyl, aryl, aralkyl, —OH, —NH, —NHR, or —OR, where R is lower alkyl or aryl-lower alkyl; and A is —CH— or —N—; and pharmaceutically acceptable salts thereof.

US Patent:

20020174096, Nov 21, 2002

Filed:

Oct 11, 2001

Appl. No.:

09/977064

Inventors:

David O'Reilly - Mountain View CA, US
Alan H. Roter - Mountain View CA, US
Keith Bostian - Mountain View CA, US
David Morgans - Los Altos CA, US

International Classification:

G06F007/00

US Classification:

707/001000

Abstract:

An interactive system for facilitating hypothesis construction by correlating and presenting gene expression data, bioassay data, and compound activity data, and associating gene and compound function information with product information, and facilitating product purchase, is disclosed.

US Patent:

20020183393, Dec 5, 2002

Filed:

Sep 14, 2001

Appl. No.:

09/952748

Inventors:

David Morgans - Los Altos CA, US
Teri Melese - Cupertino CA, US
Stuart Tugendreich - Mountain View CA, US

International Classification:

A61K031/18
C07C311/15
C07C311/37

US Classification:

514/602000, 514/603000, 564/084000, 564/085000, 564/089000

Abstract:

Compounds of formula 1: wherein Rand Rare each independently —OH or —OR; Ris —H or —R; and Rand Rare each independently —H, halo, —NO, —SH, —SR, —OH, —OR, —NH, —NHR, or —NRR, where R is lower alkyl, and pharmaceutically acceptable salts, esters and amides thereof; are effective inhibitors of RhoC.

US Patent:

20040053948, Mar 18, 2004

Filed:

May 8, 2003

Appl. No.:

10/434987

Inventors:

Andrew McDonald - San Francisco CA, US
Gustave Bergnes - Pacifica CA, US
David Morgans - Los Altos CA, US

Assignee:

Cytokinetics, Inc.

International Classification:

A61K031/517
A61K031/4709
C07D417/02
C07D413/02
C 07D 4 3/02

US Classification:

514/266200, 514/266230, 514/309000, 544/284000, 546/142000

Abstract:

Quinazolinedione derivatives useful for treating cellular proliferative disorders and disorders associated with Kif15 kinesin activity are described.

US Patent:

20040077662, Apr 22, 2004

Filed:

May 2, 2003

Appl. No.:

10/429195

Inventors:

Han-Jie Zhou - Foster City CA, US
David Morgans - Los Altos CA, US
Gustave Bergnes - Pacifica CA, US
Steven Knight - West Chester PA, US
Kenneth Newlander - West Chester PA, US
Dashyant Dhanak - West Chester PA, US
Nicholas Adams - Royers Ford PA, US

Assignee:

Cytokinetics, Inc.

International Classification:

A61K031/517
A61K031/519
A61K031/513

US Classification:

514/258100, 514/266200, 514/266300, 514/269000, 544/284000, 544/320000

Abstract:

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

US Patent:

20040077668, Apr 22, 2004

Filed:

May 8, 2003

Appl. No.:

10/435069

Inventors:

Bainian Feng - Foster City CA, US
Gustave Bergnes - Pacificia CA, US
David Morgans - Los Altos CA, US
Dashyant Dhanak - West Chester PA, US
Steven Knight - West Chester PA, US
Michael Darcy - Philadelphia PA, US

International Classification:

A61K031/517
C 07D 4 3/02

US Classification:

514/266230, 544/284000

Abstract:

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

US Patent:

20040082567, Apr 29, 2004

Filed:

Jun 12, 2003

Appl. No.:

10/462002

Inventors:

Andrew McDonald - San Francisco CA, US
Pu-Ping Lu - Foster City CA, US
Gustave Bergnes - Pacifica CA, US
David Morgans - Los Altos CA, US
Dashyant Dhanak - West Chester PA, US
Steven Knight - West Chester PA, US

International Classification:

A61K031/55
A61K031/4709
C 07D 4 3/02
C 07D 4 1/02
C07D217/22

US Classification:

514/217070, 514/309000, 546/141000, 540/597000

Abstract:

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

US Patent:

20040082638, Apr 29, 2004

Filed:

Apr 11, 2003

Appl. No.:

10/412712

Inventors:

Andrew McDonald - San Francisco CA, US
Gustave Bergnes - Pacifica CA, US
Bainian Feng - Foster City CA, US
David Morgans - Los Altos CA, US
Steven Knight - West Chester PA, US
Kenneth Newlander - West Chester PA, US
Dashyant Dhanak - West Chester PA, US
Christopher Brook - Philadelphia PA, US

Assignee:

Cytokinetics, Inc.

International Classification:

A61K031/4178
A61K031/4025
A61K031/353
C 07D 4 5/02

US Classification:

514/397000, 514/422000, 514/456000, 548/311400, 548/525000, 549/401000

Abstract:

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.