David Milunic

US Patent:

7896167, Mar 1, 2011

Filed:

Aug 5, 2005

Appl. No.:

11/659568

Inventors:

David Milunic - Deptford NJ, US
Donald Russell - Cherry Hill NJ, US

Assignee:

Akers Biosciences, Inc. - Thorofare NJ

International Classification:

B01D 29/00
B01D 29/05

US Classification:

210505, 210483, 210488, 210489, 210490, 210491, 2105001, 210503, 210504, 210506, 210508, 422101

Abstract:

A novel composite of glass fiber paper and reinforcing material that is useful for high speed manufacturing of devices comprising it is disclosed. The composite is formed by pressing into a glass fiber paper, having multimodal (at least bi-modal) composition, a hydrophilic reinforcing material. The composite has anisotropic separation properties that are particularly useful for preparing a fluid fraction from whole blood. The preferred glass fiber paper comprises glass fibers such that there are a plurality of short fibers () having large diameters and long fibers () with smaller diameters. The preferred glass fiber paper also exhibits partial ordering. There are many more of the long fibers () with smaller diameters than of the short fibers () having large diameters. Also disclosed are several blood separator device designs for efficiently separating the fluid fraction of blood from whole blood using the composite.

US Patent:

8097171, Jan 17, 2012

Filed:

Jan 26, 2011

Appl. No.:

13/014015

Inventors:

David Milunic - Deptford NJ, US
Donald Russell - Cherry Hill NJ, US

Assignee:

Akers Biosciences, Inc. - Thorofare NJ

International Classification:

B01D 37/00
B01D 29/00
B01D 29/05

US Classification:

210767, 210483, 210488, 210489, 210490, 210491, 2105001, 210503, 210504, 210505, 210506, 210508, 210800

Abstract:

A novel composite of glass fiber paper and reinforcing material that is useful for high speed manufacturing of devices comprising it is disclosed. The composite is formed by pressing into a glass fiber paper, having multimodal (at least bi-modal) composition, a hydrophilic reinforcing material. The composite has anisotropic separation properties that are particularly useful for preparing a fluid fraction from whole blood. The preferred glass fiber paper comprises glass fibers such that there are a plurality of short fibers () having large diameters and long fibers () with smaller diameters. The preferred glass fiber paper also exhibits partial ordering. There are many more of the long fibers () with smaller diameters than of the short fibers () having large diameters. Also disclosed are several blood separator device designs for efficiently separating the fluid fraction of blood from whole blood using the composite.

US Patent:

20060172438, Aug 3, 2006

Filed:

Oct 4, 2005

Appl. No.:

11/244197

Inventors:

David Milunic - Deptford NJ, US
Susan Andrelczyk - West Deptford NJ, US

International Classification:

G01N 33/551
G01N 33/553

US Classification:

436524000, 436526000

Abstract:

Methods for determining the presence of heparin/platelet factor 4 antibodies in a sample suspected to contain heparin/platelet factor 4 antibodies are provided, along with apparatus suitable for performing the methods. The method depends upon a color visualization indicating the presence or absence of heparin/platelet factor 4 antibodies in the sample. Preferred methods comprise contacting the sample with particles being complexed to platelet factor 4 (PF4) and which particle-complexed PF4 reacts specifically with heparin/platelet factor 4 antibodies, passing the sample/particle mixture through a filter, and then analyzing the color of the filtrate. The presence of heparin/platelet factor 4 antibodies in the sample is established where the color of the filtrate is substantially different from the color of the receptor-bearing particles.

US Patent:

20140004547, Jan 2, 2014

Filed:

Mar 22, 2012

Appl. No.:

14/004383

Inventors:

Yli Remo Vallejo - Newark DE, US
David Milunic - Newark DE, US

Assignee:

ANP Technologies Inc. - Newark DE

International Classification:

G01N 21/64

US Classification:

435 20, 4352887

Abstract:

A device and method for the rapid on-site detection of inhibitors of enzymes, such as, acetylcholinesterase is described where the device contains 2 reaction zones containing a reporter enzyme substrate. One reaction zone is for the test sample while the other is for an onboard negative control. Sample and control fluids are preincubated with the enzyme in separate reaction containers, then an aliquot of each reaction mixture is added to designated reaction zones on the test device. A purpose-built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.

US Patent:

57888639, Aug 4, 1998

Filed:

Dec 13, 1995

Appl. No.:

8/571572

Inventors:

David Milunic - Cockeysville MD

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

B01D 6100

US Classification:

210651

Abstract:

The present invention relates to an apparatus and method for conducting an assay using reverse flow through a membrane. More particularly, the present invention is directed to an apparatus and method which allows for the assaying of analytes, such as antigens, in a fluid sample containing such analytes with more accurate and reproducible results.

US Patent:

20150368691, Dec 24, 2015

Filed:

Jan 22, 2014

Appl. No.:

14/762914

Inventors:

- Newark DE, US
David Milunic - Newark DE, US
Ray Yin - Newark DE, US
Renee Street - Bel Air MD, US
De Chen - Newark DE, US

International Classification:

C12Q 1/46

Abstract:

A device and method for the rapid on-site detection of inhibitors of enzymes, such as acetylcholinesterase, is described wherein the device contains all reagents added to a sample pad containing dried releasable enzyme creating a reaction mixture wherein inhibitor deactivates the enzyme, while said reaction mixture travels via a longitudinal membrane to a distal porous pad containing a substrate for the enzyme. The reaction of the enzyme and the substrate results in a product that can generate a measurable signal such as color, fluorescence or luminescence to serve as a reporter. Signal that is generated at this reaction zone is inversely proportional to inhibitor concentration in the test sample. A device containing two such strips, one for a test sample, the other for a negative control fluid as an onboard comparator is described. A purpose-built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.

US Patent:

20150353987, Dec 10, 2015

Filed:

Aug 17, 2015

Appl. No.:

14/827674

Inventors:

- Newark DE, US
David Milunic - Newark DE, US

International Classification:

C12Q 1/44
G01N 21/64
C12Q 1/46

Abstract:

A device and method for the rapid on-site detection of inhibitors of enzymes, such as, acetylcholinesterase is described where the device contains 2 reaction zones containing a reporter enzyme substrate. One reaction zone is for the test sample while the other is for an onboard negative control. Sample and control fluids are preincubated with the enzyme in separate reaction containers, then an aliquot of each reaction mixture is added to designated reaction zones on the test device. A purpose-built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.