David Joseph Lefer

Author:

David Lefer

ISBN #:

0316013854

Author:

David Lefer

ISBN #:

0316277665

US Patent:

20100204099, Aug 12, 2010

Filed:

May 28, 2008

Appl. No.:

12/451524

Inventors:

Nir Barzilai - Hartsdale NY, US
Pinchas Cohen - Pacific Palisades CA, US
Radhika Muzumdar - Mamaroneck NY, US
David Lefer - Bronx NY, US

International Classification:

A61K 38/16
A61K 38/10
A61P 3/10

US Classification:

514 12, 514 13

Abstract:

Provided are methods of using humanin and humanin analogs to treat a mammal exhibiting or at risk for insulin resistance, increase insulin sensitivity in a mammal exhibiting or at risk for insulin resistance, treat type-2 diabetes mellitus, metabolic syndrome, and neurodegeneration, treat and prevent myocardial injury, and determine longevity.

US Patent:

20130045916, Feb 21, 2013

Filed:

Oct 9, 2012

Appl. No.:

13/647453

Inventors:

Nir Barzilai - Hartsdale NY, US
Pinchas Cohen - Pacific Palisades CA, US
Radhika Muzumdar - Mamaroneck NY, US
David Lefer - Decatur GA, US

Assignee:

The Regeants of the University of California - Oakland CA
Albert Einstein College of Medicine of Yeshiva University - Bronx NY

International Classification:

A61K 38/17
A61P 3/10

US Classification:

514 69

Abstract:

Provided are methods of using humanin and humanin analogs to treat a mammal exhibiting or at risk for insulin resistance, increase insulin sensitivity in a mammal exhibiting or at risk for insulin resistance, treat type-2 diabetes mellitus, metabolic syndrome, and neurodegeneration, treat and prevent myocardial injury, and determine longevity.

US Patent:

20070154569, Jul 5, 2007

Filed:

Jul 9, 2004

Appl. No.:

10/563683

Inventors:

Mark Gladwin - Washington DC, US
Alan Schechter - Bethesda MD, US
David Lefer - Bronx NY, US
Rakesh Patel - Birmingham AL, US
Christian Hunter - Bethesda MD, US
Gordon Power - Redlands CA, US
Daniel Kim-Shapiro - Winston-Salem NC, US
Ryszard Pluta - Bethesda MD, US
Edward Oldfield - Philomont VA, US
Richard Cannon - Potomac MD, US

Assignee:

The Govt. of the U.S.A. through The Dept. of Health and Human Services - Rockville MD
The University of Alabama Research Foundation - Birmingham AL
Wake Forest University - Winston-Salem NC
Loma Linda University - Loma Linda CA
The Board of Supervisors of Louisiana State University - Shreveport LA

International Classification:

A61K 33/00
A61P 9/00
A01N 59/00
A61P 11/00

US Classification:

424718000

Abstract:

It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

US Patent:

20170253622, Sep 7, 2017

Filed:

Mar 2, 2017

Appl. No.:

15/447797

Inventors:

- Pullman WA, US
- Baton Rouge LA, US
David J. Lefer - Saint Bernard LA, US

International Classification:

C07F 9/40
C07F 9/572

Abstract:

The embodiments herein generally relates to compounds and methods for releasing HS in a pH dependent manner. In particular, the invention provides compounds of various formulations which release HS in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of HS.

US Patent:

20150064286, Mar 5, 2015

Filed:

Sep 13, 2012

Appl. No.:

14/345044

Inventors:

Gabriel Gojon-Romanillos - San Pedro Garza García, MX
Gabriel Gojon-Zarrilla - San Pedro Garza Garcia, MX
David J. Lefer - New Orleans LA, US

Assignee:

EMORY UNIVERSITY - Atlanta GA
NUEVAS ALTERNATIVAS NATURALES, S.A.P.I. DE C.V. - Monterrey NL

International Classification:

A61K 33/04
A61K 45/06

US Classification:

424705

Abstract:

The present invention features sulfur-rich compositions and preparations thereof that are safe and effective as hydrogen sulfide prodrugs of high bioavailability. The invention also includes methods of treating pathological conditions associated with oxidative stress using sulfur-rich compositions. The invention further includes sulfur-rich compositions as antidotes and medical food for preserving and promoting general health.