David C Delaney

US Patent:

6533767, Mar 18, 2003

Filed:

Jan 30, 2001

Appl. No.:

09/774469

Inventors:

Peter Johansson - Campbell CA
David Delaney - Los Gatos CA
Brent Constantz - Menlo Park CA

Assignee:

Corazon Technologies, Inc. - Menlo Park CA

International Classification:

A61M 3100

US Classification:

604507, 604508, 604509, 604264, 604 9601, 604912

Abstract:

Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e. g. , an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. Examples of dissolution fluid/dissolution fluid attenuating fluid pairs include: (1) oxidizing agent fluid and fluid comprising oxidizable neutralizing agent; (2) surfactant fluid and phosphate buffered saline; (3) acidic solution and phosphate buffered saline; etc. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e. g. increased or established.

US Patent:

7141045, Nov 28, 2006

Filed:

Oct 4, 2002

Appl. No.:

10/265174

Inventors:

Peter Johansson - Campbell CA, US
David Delaney - Los Gatos CA, US
Brent Constantz - Menlo Park CA, US

Assignee:

Corazon Technologies, Inc. - Menlo Park CA

International Classification:

A61M 31/00
A61M 29/00
A61M 5/00

US Classification:

604508, 604 9601, 604264, 604912

Abstract:

Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e. g. , an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.

US Patent:

7175858, Feb 13, 2007

Filed:

Jul 26, 2004

Appl. No.:

10/900029

Inventors:

Brent R. Constantz - Cupertino CA, US
David Delaney - Scotts Valley CA, US
Duran Yetkinler - Cupertino CA, US

Assignee:

Skeletal Kinetics LLC - Cupertino CA

International Classification:

A61K 9/00
A61K 9/14
A61K 33/42
A61K 31/695
A61K 59/26
A01N 55/00

US Classification:

424602, 424 57, 424400, 424423, 424484, 424489, 424601, 424615, 514 63, 514951, 514955

Abstract:

Methods and compositions for producing flowable compositions, e. g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e. g. , bone defects.

US Patent:

7252672, Aug 7, 2007

Filed:

Mar 9, 2004

Appl. No.:

10/797907

Inventors:

Duran Yetkinler - Cupertino CA, US
David Delaney - Scotts Valley CA, US
Brent R. Constantz - Menlo Park CA, US

Assignee:

Skeletal Kinetics, LLC - Cupertino CA

International Classification:

A61B 17/58
A61F 2/00

US Classification:

606 92

Abstract:

Methods of employing bone defect filling, e. g. , orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e. g. , in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.

US Patent:

7252833, Aug 7, 2007

Filed:

Nov 18, 2003

Appl. No.:

10/717171

Inventors:

Brent R. Constantz - Menlo Park CA, US
David Delaney - Scotts Valley CA, US

Assignee:

Skeletal Kinetics, LLC - Cupertino CA

International Classification:

A61K 33/42
A61K 31/00
A61K 31/695
A61F 2/00
A01N 59/26
A01N 61/00
A01N 55/00

US Classification:

424423, 424 7012, 424602, 514 1, 514 63

Abstract:

Methods and compositions are provided for producing flowable compositions, e. g. pastes, that set into calcium phosphate products that include an osteoclastogenic agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid and an osteoclastogenic agent, e. g. , RANKL or a mimetic thereof, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.

US Patent:

7252841, Aug 7, 2007

Filed:

May 20, 2004

Appl. No.:

10/850985

Inventors:

Brent R. Constantz - Cupertino CA, US
David Delaney - Scotts Valley CA, US
Duran Yetkinler - Cupertino CA, US

Assignee:

Skeletal Kinetics, LLC - Cupertino CA

International Classification:

A61K 9/00
A61K 9/14
A61K 33/42
A61F 2/00
A01N 59/26

US Classification:

424489, 424423, 424484, 424601, 424602

Abstract:

Methods are provided for producing compositions, e. g. pastes or clays, which rapidly set into high-strength calcium phosphate products. In the subject methods, dry reactants that include calcium and phosphate sources, as well as a monovalent cation dihydrogen phosphate salt, are combined with a setting fluid and the combined reactants are mixed to produce the settable composition. A feature of the invention is that cements rapidly set into high strength product compositions. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.

US Patent:

7306786, Dec 11, 2007

Filed:

Jul 28, 2003

Appl. No.:

10/629321

Inventors:

David Delaney - Scotts Valley CA, US
Brent Constantz - Cupertino CA, US

Assignee:

Skeletal Kinetics, LLC - Cupertino CA

International Classification:

A61K 49/04

US Classification:

424 941, 424 111, 424 165, 424 137, 424 94

Abstract:

Methods are provided for producing flowable compositions, e. g. pastes, that set into calcium phosphate products and include a contrast agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with setting fluid and a water-soluble contrast agent, e. g. , a water-soluble barium salt, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e. g. , bone defects.

US Patent:

7901650, Mar 8, 2011

Filed:

Jun 22, 2005

Appl. No.:

11/165564

Inventors:

David Delaney - Scotts Valley CA, US

Assignee:

Skeletal Kinectics, LLC - Cupertino CA

International Classification:

C01B 25/26
A61K 31/78

US Classification:

423308, 424423

Abstract:

Methods are provided for producing porous β-Tricalcium Phosphate (β-TCP). In the subject methods, β-TCP is combined with graphite to produce an intermediate greenware product. The intermediate greenware product is then sintered to produce porous β-TCP. The subject methods and compositions produced thereby find use in a variety of applications.

Author:

David Delaney

ISBN #:

0292715978

Author:

David Delaney

ISBN #:

0521831261

Author:

David Delaney

ISBN #:

0631220151