David Crich

Author:

David Crich

ISBN #:

0125087608

Author:

David Crich

ISBN #:

0470066520

US Patent:

6362229, Mar 26, 2002

Filed:

Aug 17, 2000

Appl. No.:

09/640890

Inventors:

Penelope N. Markham - Oak Park IL
Debbie C. Mulhearn - Wheaton IL
Alexander A. Neyfakh - Oak Park IL
David Crich - Chicago IL
Michael E. Johnson - Winntka IL

Assignee:

Influx, Inc. - Chicago IL

International Classification:

A61K 3117

US Classification:

514596, 564 48, 564 53, 546112, 546134, 546139, 546152, 514311

Abstract:

The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or antifungal agents to increase the toxic effects of the antimicrobial agents. More specifically, the present invention provides methods and compositions for enhancing the antibacterial action of fluoroquinolones by administering fluoroquinolones in combination with an inhibitor of multidrug transporters and of enhancing the antifungal action of azole antifungal agents by administering an azole antifungal agent in combination with an inhibitor of multidrug transporters. Compositions comprising indole, urea, quinoline or aromatic amide based inhibitors also are disclosed.

US Patent:

6620972, Sep 16, 2003

Filed:

Jun 18, 2002

Appl. No.:

10/174269

Inventors:

David Crich - Chicago IL
Santhosh Neelamkavil - Chicago IL

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

C07C31700

US Classification:

568 27, 568420, 568303

Abstract:

A method of oxidizing primary and secondary alcohols to an aldehyde or ketone using a fluorous sulfoxide or a fluorous sulfide is disclosed. The method includes regenerating and recycling the fluorous sulfoxide.

US Patent:

6849767, Feb 1, 2005

Filed:

Jul 24, 2003

Appl. No.:

10/625982

Inventors:

David C. Crich - Chicago IL, US
Santhosh Neelamkavil - Philadelphia PA, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

C07C 502

US Classification:

568 6, 536 181, 548429, 564375, 564391, 568705, 568814, 568820, 568832, 568880, 568910

Abstract:

A method of hydroborating an alkene or alkyne, or reducing an organic functionality, oxidizing primary and secondary alcohols using a fluorous borane-sulfide is disclosed. The method includes regeneration and recycling the fluorous borane-sulfide.

US Patent:

6960654, Nov 1, 2005

Filed:

Jun 2, 2003

Appl. No.:

10/452734

Inventors:

David C. Crich - Chicago IL, US
Mark Smith - Chicago IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

C07G003/00
C07H015/00
C07H017/00

US Classification:

536 185, 536 41, 536 172, 536 175, 536124, 536 111

Abstract:

A method of forming a glycosidic bond utilizing an activated thioglycoside is disclosed. The thioglycoside is activated by an N,N-dialkylsulfinamide and trifluoromethanesulfonic anhydride. The method allows the facile synthesis of disaccharides, oligosacchraides, and polysaccharides in solution or on a polymer support.

US Patent:

20020193369, Dec 19, 2002

Filed:

Nov 2, 2001

Appl. No.:

10/008375

Inventors:

Penelope Markham - Oak Park IL, US
Alexander Neyfakh - Chicago IL, US
Yongzhi Xuan - Chicago IL, US
David Crich - Chicago IL, US
Michael Johnson - Winnetka IL, US
Debbie Mulhearn - Wheaton IL, US

International Classification:

A61K031/5415
A61K031/538
A61K031/496

US Classification:

514/224200, 514/230500, 514/254070, 514/396000

Abstract:

The present invention provides compounds which, when used in combination with antifungal azoles, offer enhanced antifungal therapy. More particularly, these compositions (including carbazoles or triptycenes) can convert fungistatic drugs such as fluconazole into fungicidal drugs.

US Patent:

20030125337, Jul 3, 2003

Filed:

Mar 26, 2002

Appl. No.:

10/106839

Inventors:

Penelope Markham - Oak Park IL, US
Debbie Mulhearn - Wheaton IL, US
Alexander Neyfakh - Oak Park IL, US
David Crich - Chicago IL, US
Michael Johnson - Winntka IL, US

Assignee:

Influx, Inc.

International Classification:

A61K031/496
A61K031/4709
A61K031/47
A61K031/405

US Classification:

514/253080, 514/312000, 514/410000, 514/415000

Abstract:

The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or antifungal agents to increase the toxic effects of the antimicrobial agents. More specifically, the present invention provides methods and compositions for enhancing the antibacterial action of fluoroquinolones by administering fluoroquinolones in combination with an inhibitor of multidrug transporters and of enhancing the antifungal action of azole antifungal agents by administering an azole antifungal agent in combination with an inhibitor of multidrug transporters. Compositions comprising indole, urea, quinoline or aromatic amide based inhibitors also are disclosed.

US Patent:

20030225126, Dec 4, 2003

Filed:

Mar 23, 2001

Appl. No.:

09/816761

Inventors:

Penelope Markham - Oak Park IL, US
Debbie Mulhearn - Wheaton IL, US
Ekaterina Klyachko - Chicago IL, US
Alexander Neyfakh - Chicago IL, US
David Crich - Chicago IL, US
Michael Johnson - Winnetka IL, US

Assignee:

Influx, Inc. - Chicago IL

International Classification:

A61K031/47
A61K031/175

US Classification:

514/312000, 514/615000

Abstract:

The present invention relates generally to the field of bacteriology. More particularly, the present invention provides methods and compositions for increasing the effectiveness of existing antibacterial agents and methods of overcoming bacterial resistance. Specifically, the invention provides methods of enhancing the action of an antibacterial agent by use of an antibiotic potentiator. Compositions of antibiotic potentiators including an acyl hydrazide, an oxy amide, and an 8-hydroxy quinoline also are disclosed.

US Patent:

20050043369, Feb 24, 2005

Filed:

Jul 23, 2004

Appl. No.:

10/897873

Inventors:

Penelope Markham - Oak Park IL, US
Debbie Mulhearn - Wheaton IL, US
Ekaterina Klyachko - Chicago IL, US
Alexander Neyfakh - Chicago IL, US
David Crich - Chicago IL, US
Michael Johnson - Winnetka IL, US

Assignee:

Protez Pharmaceuticals Inc. - Malvern PA
The Board of Trustees of The University of Illinois - Chicago IL

International Classification:

A61K031/44
A61K031/27
A61K031/16
A61K031/175
A61K031/325

US Classification:

514357000, 514482000, 514614000, 514590000

Abstract:

The present invention relates generally to the field of bacteriology. More particularly, the present invention provides methods and compositions for increasing the effectiveness of existing antibacterial agents and methods of overcoming bacterial resistance. Specifically, the invention provides methods of enhancing the action of an antibacterial agent by use of an antibiotic potentiator. Compositions of antibiotic potentiators including an acyl hydrazide, an oxy amide, and an 8-hydroxy quinoline also are disclosed.