Jane Nichols - Bloomington MN, US Teri Buseman - Minnetonka MN, US David Rolf - Eden Prairie MN, US David Brandwein - New Brighton MN, US Daniel McWhorter - Eagan MN, US
International Classification:
A61K031/56 A61K031/60 A61L015/16
US Classification:
424/447000, 514/171000, 514/159000
Abstract:
The present invention provides a water insoluble, protective, adhesive skin patch useful for treating or preventing psoriasis, dermatitis, and/or eczema. The adhesive patch includes a backing that is treated with a sizing agent (e.g., a fluorocarbon solution, a silicone-containing compound, or a combination thereof). The present invention also provides a method for treating or preventing at least one of psoriasis, dermatitis, and eczema in a mammal (e.g., human) and a method for exfoliating the skin surface of a mammal.
Transdermal Administration Of N-(2,5-Disubstituted Phenyl)-N'-(3-Substituted Phenyl)-N'-Methyl Guanidines
William Van Osdol - Mountain View CA, US Robert Gale - Los Altos CA, US David Brandwein - New Brighton MN, US Rama Padmanabhan - Los Altos CA, US Joan Sunram - Coon Rapids MN, US
International Classification:
A61K009/70 A61K031/155
US Classification:
424/449000, 514/634000
Abstract:
Composition of matter for application to a body surface or membrane to administer a N-(2,5-Disubstituted phenyl)-N′-(3-substituted phenyl)-N′-methyl guanidine by permeation through the body surface or membrane, the composition comprising the guanidine compound to be administered, at a therapeutically effective rate, optionally in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices and methods for the transdermal administration of a guanidine for the prevention of neuropathic pain, neuropsychological deficits resulting from cardiac surgery (CABG), and other neurological disorders.
Transdermal Administration Of N-(2,5-Disubstituted Phenyl)-N'-(3-Substituted Phenyl)-N'-Methyl Guanidines
William Van Osdol - Mountain View CA, US Robert Gale - Los Altos CA, US David Brandwein - New Brighton MN, US Rama Padmanabhan - Los Altos CA, US Joan Sunram - Coon Rapids MN, US
International Classification:
A61K009/70 A61L015/16
US Classification:
424/449000
Abstract:
Composition of matter for application to a body surface or membrane to administer a N-(2,5-Disubstituted phenyl)-N′-(3-substituted phenyl)-N′-methyl guanidine by permeation through the body surface or membrane, the composition comprising the guanidine compound to be administered, at a therapeutically effective rate, optionally in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices and methods for the transdermal administration of a guanidine for the prevention of neuropathic pain, neuropsychological deficits resulting from cardiac surgery (CABG), and other neurological disorders.
David H. Brandwein - New Brighton MN, US Franklyn L. Frderickson - White Bear Lake MN, US Karl M. Kropp - Saint Paul MN, US
International Classification:
A61M 5/158
US Classification:
604272
Abstract:
A microneedle application device for moving a microneedle array toward a target skin location includes a feedback sensor. The feedback sensor is operably connected to the microneedle application device, and is capable of generating an output corresponding to forces between the target skin location and the microneedle application device.