Darren P Gray

US Patent:

20080090239, Apr 17, 2008

Filed:

Jun 13, 2007

Appl. No.:

11/762747

Inventors:

DANIEL SHOEMAKER - San Diego CA, US
Martin Fuchs - Uxbridge MA, US
Neil Krueger - Roslindale MA, US
Mehmet Toner - Wellesley Hills MA, US
Darren Gray - Brookline MA, US
Ravi Kapur - Stoughton MA, US
Zihua Wang - Newton MA, US

International Classification:

C12Q 1/20
C12Q 1/68
G01N 33/53

US Classification:

435006000, 435029000, 435007230

Abstract:

Described herein are methods to diagnose or prognose cancer in a subject by enriching, detecting, and analyzing individual rare cells, e.g., epithelial cells, in a sample from the subject. Also described are methods for labeling regions of genomic DNA in individual cells in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the method includes detecting the presence of gene mutations in individual rare cells in a subsample.

US Patent:

20080220422, Sep 11, 2008

Filed:

Jun 14, 2007

Appl. No.:

11/763421

Inventors:

Daniel Shoemaker - San Diego CA, US
Martin Fuchs - Uxbridge MA, US
Neil X. Krueger - Roslindale MA, US
Mehmet Toner - Wellesley Hills MA, US
Darren Gray - Brookline MA, US
Ravi Kapur - Stoughton MA, US
Zihua Wang - Newton MA, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.

US Patent:

20100136529, Jun 3, 2010

Filed:

Sep 2, 2008

Appl. No.:

12/230628

Inventors:

Daniel Shoemaker - San Diego CA, US
Martin Fuchs - Uxbridge MA, US
Neil X. Krueger - Roslindale MA, US
Mehmet Toner - Wellesley Hills MA, US
Darren Gray - Brookline MA, US
Ravi Kapur - Stoughton MA, US
Zihua Wang - Newton MA, US

International Classification:

C12Q 1/68
G01N 33/53
G06N 5/02

US Classification:

435 6, 436 94, 706 54

Abstract:

The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.

US Patent:

20120171666, Jul 5, 2012

Filed:

Nov 29, 2011

Appl. No.:

13/306640

Inventors:

Daniel Shoemaker - San Diego CA, US
Martin Fuchs - Uxbridge MA, US
Neil X. Krueger - Roslindale MA, US
Mehmet Toner - Wellesley Hills MA, US
Darren Gray - Brookline MA, US
Ravl Kapur - Stoughton MA, US
Zihua Wang - Newton MA, US

International Classification:

G01N 27/62

US Classification:

435 61

Abstract:

The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.

US Patent:

20120171667, Jul 5, 2012

Filed:

Nov 29, 2011

Appl. No.:

13/306698

Inventors:

Daniel SHOEMAKER - San Diego CA, US
Martin FUCHS - Uxbridge MA, US
Neil X. KRUEGER - Roslindale MA, US
Mehmet TONER - Wellesley Hills MA, US
Darren GRAY - Brookline MA, US
Ravi KAPUR - Stoughton MA, US
Zihua WANG - Newton MA, US

International Classification:

G01N 27/62

US Classification:

435 61

Abstract:

The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.

US Patent:

58593667, Jan 12, 1999

Filed:

Apr 29, 1997

Appl. No.:

8/841063

Inventors:

Michael R. Van Driel - Fountain Valley CA
Darren S. Gray - Grand Junction CO
Victor C. H. Lam - Honolulu HI
Jill E. Uyeno - Honolulu HI
Yu-Tung Wong - Huntington Beach CA

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61B 600

US Classification:

73149

Abstract:

The blood volume contained in a soft-shell venous reservoir is measured by using strain gauges to detect variations in the expansion stress imposed upon the reservoir material or a film overlying the reservoir as the reservoir fills.

US Patent:

57569401, May 26, 1998

Filed:

Apr 29, 1997

Appl. No.:

8/840687

Inventors:

Michael R. Van Driel - Fountain Valley CA
Darren S. Gray - Grand Junction CO
Victor C. H. Lam - Honolulu HI
Amy P. Noss - Westerville OH
Jill E. Uyeno - Honolulu HI
Yu-Tung Wong - Huntington Beach CA

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01G 900

US Classification:

177245

Abstract:

An accurate real-time volume measurement of the blood content of a soft-shell venous reservoir is obtained by computing the volume from the weight of the blood in the reservoir modified by the hematocrit of the blood.

US Patent:

58230459, Oct 20, 1998

Filed:

Apr 29, 1997

Appl. No.:

8/840688

Inventors:

Michael R. Van Driel - Fountain Valley CA
Darren S. Gray - Grand Junction CO
Victor C.H. Lam - Honolulu HI
Jill E. Uyeno - Honolulu HI
Yu-Tung Wong - Huntington Beach CA

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01F 2300

US Classification:

73299

Abstract:

The blood volume in a soft-shell venous reservoir is measured by immersing the reservoir in a fluid and measuring the displacement of that fluid, either by measuring a liquid level in an overflow tube or by measuring the temperature-compensated gas pressure if the displaced fluid is a gas in a sealed container. Equipment operable from outside the container to measure the reservoir or to expel air therefrom is also disclosed.