Daniel P Chin

US Patent:

6455026, Sep 24, 2002

Filed:

Mar 23, 2001

Appl. No.:

09/816703

Inventors:

Sabine Mueller - San Francisco CA
Thorsten Melcher - San Francisco CA
Daniel J. Chin - Foster City CA

Assignee:

AGY Therapeutics, Inc. - South San Francisco CA

International Classification:

A61K 5100

US Classification:

424 149, 424 111, 424 165, 424 91, 435 21

Abstract:

The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents that specifically bind to human protein tyrosine phosphatase-zeta (PTP ) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

US Patent:

6470277, Oct 22, 2002

Filed:

Jul 28, 2000

Appl. No.:

09/628202

Inventors:

Daniel J. Chin - Foster City CA
Donna Hendrix - Berkeley CA
Oliver Zhao - Daly City CA

Assignee:

AGY Therapeutics, Inc. - South San Francisco CA

International Classification:

G06F 1730

US Classification:

702 19, 707 3, 707 6, 707 7, 707 10, 702 27, 706 45, 706 47

Abstract:

Techniques for facilitating the identification of candidate genes from a plurality of DNA sequences. According to an embodiment of the present invention, techniques are provided for extracting and integrating information from various information sources and results of various analyses, and storing the integrated information in a form which is conducive to identification of candidate genes. The stored information may include results of a homology search for the plurality of DNA sequences, annotative information for the plurality of DNA sequences indicating the biochemical functions and physiological roles of the plurality of DNA sequences, gene expression profile data for the plurality of DNA sequences describing behavioral patterns of the plurality of DNA sequences, results from clustering the plurality of DNA sequences based on time course data as described by the gene expression profile data, and other information.

US Patent:

6660483, Dec 9, 2003

Filed:

Oct 13, 2000

Appl. No.:

09/688078

Inventors:

Kalev Kask - San Mateo CA
Thorsten Melcher - San Francisco CA
Daniel J. Chin - Foster City CA

Assignee:

AGY Therapeutics, Inc. - South San Francisco CA

International Classification:

C12Q 100

US Classification:

435 71, 435 4

Abstract:

The invention relates to a human phospholipase C expressed in the brain (B-PLC) and induced in response to ischemic brain tissue. The inventions provides methods and reagents useful for diagnosis and treatment of hypoxic-ischemic brain insult such as stroke.

US Patent:

6670138, Dec 30, 2003

Filed:

Oct 31, 2001

Appl. No.:

10/001051

Inventors:

Mirella Gonzalez-Zulueta - Pacifica CA
Mehrdad Shamloo - San Mateo CA
K.C. McFarland - Davis CA
Daniel Chin - Foster City CA
Tadeusz Wieloch - Lund, SE
Thorsten Melcher - San Francisco CA

Assignee:

AGY Therapeutics, Inc. - South San Francisco CA

International Classification:

C12Q 170

US Classification:

435 71, 435 5, 435 6, 435 792, 4241301, 530300, 530350

Abstract:

The present invention identifies a gene whose gene product provides a protective effect against neurological disorders or neuronal injuries. Further, the invention provides methods for diagnosing or assessing an individuals susceptibility to a neuronal injury such as stroke. Also provided are therapeutic methods for treating patients, and methods for prophylactically treating individuals susceptible to various neurological disorders or neuronal injuries. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered or are at risk to suffer such disorders or injuries.

US Patent:

6841351, Jan 11, 2005

Filed:

Oct 19, 2001

Appl. No.:

10/027807

Inventors:

Li Gan - San Francisco CA, US
Mirella Gonzalez-Zulueta - Pacifica CA, US
Kristin Anton - San Ramon CA, US
Richa Wilson - San Francisco CA, US
Thorsten Melcher - San Francisco CA, US
Daniel Chin - Foster City CA, US

Assignee:

AGY Therapeutics, Inc. - South San Francisco CA

International Classification:

C12Q 168
C12P 1934
C07H 2104
G01N 33566

US Classification:

435 6, 435 911, 435 912, 436501, 536 221

Abstract:

Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity and then validating the role of the candidate gene in establishment of such a cellular state or activity. Certain methods utilized RNA interference techniques in the validation process.

US Patent:

6876930, Apr 5, 2005

Filed:

Mar 4, 2002

Appl. No.:

10/090698

Inventors:

Joseph Murray - Berkeley CA, US
Donna Hendrix - Berkeley CA, US
Daniel J Chin - Foster City CA, US

Assignee:

AGY Therapeutics, Inc. - South San Francisco CA

International Classification:

G01N031/00
G01N033/48

US Classification:

702 19, 702 27

Abstract:

There is a pressing need for computer-implemented tools that can summarize and present the enormous amounts of public literature to facilitate analysis of gene expression data. The present invention provides techniques and systems for efficiently integrating public literature regarding gene function with data from gene expression profiling experiments. Information from literature databases relating to a particular set of DNA sequences of known expression pattern is retrieved, processed, cross-referenced and viewed to provide further information about a particular DNA sequence to facilitate its identification as a candidate gene.

US Patent:

7014838, Mar 21, 2006

Filed:

Dec 23, 2002

Appl. No.:

10/329258

Inventors:

Sabine Mueller - San Francisco CA, US
Mirella Gonzalez-Zulueta - Pacifica CA, US
Erik Foehr - Novato CA, US
Daniel J. Chin - Foster City CA, US

Assignee:

AGY Therapeutics, Inc. - South San Francisco CA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 169, 424 111, 424 149, 424 165, 424 91, 424 92

Abstract:

The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents, which specifically bind to one or more of the identified brain tumor protein targets. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

US Patent:

7060275, Jun 13, 2006

Filed:

Aug 28, 2003

Appl. No.:

10/652981

Inventors:

Sabine Mueller - San Francisco CA, US
Thorsten Melcher - San Francisco CA, US
Daniel Chin - Foster City CA, US

Assignee:

AGY Therapeutics, Inc. - South San Francisco CA

International Classification:

A61K 39/395
A61K 39/40
C07H 21/02

US Classification:

4241781, 436 231, 436 232, 436 235

Abstract:

The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents which specifically bind to one or more of human proteins angiopoietin related protein 2 (ARP-2,) secreted protein acidic, rich in cysteine (SPARC,) c-met proto-oncogene (C-MET,) brevican (BEHAB,) CD-44 antigen (CD-44,) tetraspanin 3 (TSPN3,) pleiotrophin (PTN,) osteopontin (OPN,) vasoactive intestinal peptide receptor-2 (VIPR-2,) and receptor protein tyrosine phosphatase zeta (PTPζ) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. The present invention also provides novel splice variants of protein PTPζ, PTPζ SM1 and PTPζ SM2.