Daniel H Castro

Author:

Daniel Castro

ISBN #:

0822339307

Author:

Daniel Castro

ISBN #:

0822339390

Author:

Daniel Castro

ISBN #:

0842026258

Author:

Daniel Castro

ISBN #:

0842026266

Author:

Daniel Castro

ISBN #:

0918038065

Author:

Daniel Castro

ISBN #:

8480486503

US Patent:

6616765, Sep 9, 2003

Filed:

Jan 10, 2002

Appl. No.:

10/043500

Inventors:

Daniel Castro - Santa Clara CA
Steven Wu - Santa Clara CA
Kevin L. Woolbright - Sunnyvale CA
Kurt W. Scheinpflug - Sunnyvale CA
Syed F. A. Hossainy - Fremont CA
Li Chen - San Jose CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

B05C 1100

US Classification:

118669, 118677, 118679, 118320

Abstract:

A patterned coating on a prosthesis, for example a stent, and a method for forming the coating are disclosed. Additionally, an apparatus for forming the patterned coating is disclosed.

US Patent:

6713119, Mar 30, 2004

Filed:

Dec 23, 1999

Appl. No.:

09/470559

Inventors:

Syed F. A. Hossainy - Fremont CA
Judy A. Guruwaiya - San Jose CA
Daniel A. Castro - Santa Clara CA
Sameer Harish - Fremont CA
Steven Z. Wu - Santa Clara CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61F 202

US Classification:

427 225, 427 21, 427 214, 427 224, 427 221, 524503, 525 56, 525 57, 623 12, 623 111, 623 112, 623 134, 623 142, 623 143, 623 146

Abstract:

A coating for a prosthesis, for example a stent, and a composition for forming the coating is disclosed. The coating can serve as a primer, allowing substances, such as polymers, to be effectively secured by the prosthesis. Alternatively, the coating can serve as a reservoir, allowing for the local and sustained release of a therapeutic substance to biological tissues. The composition can be formed from an ethylene vinyl alcohol copolymer and a dimethylsulfoxide solvent, with or without a therapeutic substance. Alternatively, the composition can be formed from an ethylene vinyl alcohol copolymer, a dimethylsulfoxide solvent, and a wetting fluid, with or without a therapeutic substance. The composition is applied to a surface of the prosthesis and essentially all of the dimethylsulfoxide solvent or dimethylsulfoxide solvent/wetting fluid is removed or allowed to evaporate to form the coating.

US Patent:

6716444, Apr 6, 2004

Filed:

Sep 28, 2000

Appl. No.:

09/676049

Inventors:

Daniel Castro - Santa Clara CA
Stephen D. Pacetti - San Jose CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61F 1300

US Classification:

424422, 424400, 424423, 424424, 424426

Abstract:

A drug eluting medical device is disclosed. The device includes a barrier layer for reducing the rate of release of a drug.

US Patent:

6953560, Oct 11, 2005

Filed:

Oct 3, 2003

Appl. No.:

10/678346

Inventors:

Daniel Castro - Santa Clara CA, US
Stephen D. Pacetti - San Jose CA, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61F002/02

US Classification:

423423, 623 11, 623 115, 623 123

Abstract:

An implantable medical device and methods for making the implantable medical device are disclosed. The implantable medical device includes a substrate. At least a portion of the substrate is coated with a first layer including a polymer containing a drug. A barrier overlies the first layer. The barrier significantly reduces the rate of release of the drug from the polymer, thereby sustaining release of the drug from the medical device for a longer time. The barrier may be a homogeneous layer overlying the first layer, or a number of discrete deposits over the first layer. Alternatively, the barrier may be intermixed with an outer portion of the first layer. The barrier material is biocompatible, and typically has a thickness ranging from about 50 angstroms to about 20,000 microns. Suitable materials for the barrier include, but are not limited to, inorganic compounds, such as inorganic silicides, oxides, nitrides, carbides, as well as pure metals such as aluminum, chromium, gold, hafnium, iridium, niobium, palladium, platinum, tantalum, titanium, tungsten, zirconium, and alloys of these metals. The barriers disclosed may be applied to the first layer by several techniques, depending on the material being applied.

US Patent:

7323210, Jan 29, 2008

Filed:

Jun 23, 2003

Appl. No.:

10/602487

Inventors:

Daniel Castro - Santa Clara CA, US
Steven Wu - Santa Clara CA, US
Kevin L. Woolbright - Sunnyvale CA, US
Kurt W. Scheinpflug - Sunnyvale CA, US
Syed F. A. Hossainy - Fremont CA, US
Li Chen - San Jose CA, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

B05D 1/00

US Classification:

427 225

Abstract:

A patterned coating on a prosthesis, for example a stent, and a method for forming the coating are disclosed. Additionally, an apparatus for forming the patterned coating is disclosed.

US Patent:

7455876, Nov 25, 2008

Filed:

Jul 11, 2007

Appl. No.:

11/776448

Inventors:

Daniel Castro - Santa Clara CA, US
Steven Wu - Santa Clara CA, US
Kevin L. Woolbright - Sunnyvale CA, US
Kurt W. Scheinpflug - Sunnyvale CA, US
Syed F. A. Hossainy - Fremont CA, US
Li Chen - San Jose CA, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

B05D 1/00

US Classification:

427 224, 427 225

Abstract:

A patterned coating on a prosthesis, for example a stent, and a method for forming the coating are disclosed Additionally, an apparatus for forming the patterned coating is disclosed.

US Patent:

7666342, Feb 23, 2010

Filed:

Jun 29, 2007

Appl. No.:

11/771967

Inventors:

Timothy A. Limon - Cupertino CA, US
Daniel A. Castro - Santa Clara CA, US
David C. Gale - San Jose CA, US

Assignee:

Abbott Cardiovascular Systems Inc. - Santa Clara CA

International Classification:

B29C 35/06

US Classification:

264535, 264573, 264404, 264402

Abstract:

A blow molding apparatus for expanding a polymer tube and a method for fabricating a stent using the apparatus is disclosed. The polymer tube is disposed within a tubular mold, over which a heated ring is made of a material having thermal conductivity greater than the tubular mold is translated. The ring is heated with heated fluid streams applied directly onto an outer surface of the ring, or heated fluid circulated within the ring, or an electrically resistive coil within the ring, or combinations thereof. The heated ring uniformly heats a circumference of the tubular mold that, in turn, uniformly heats a circumferential band of the polymer tube. The heated polymer tube is progressively expanded radially and axially while the ring is translated longitudinally over the polymer tube. The expanded polymer tube can be heat set and cooled prior to removal from the tubular mold.

US Patent:

7691401, Apr 6, 2010

Filed:

May 17, 2005

Appl. No.:

11/132048

Inventors:

Daniel Castro - Santa Clara CA, US
Stephen D. Pacetti - San Jose CA, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61F 2/04

US Classification:

424426, 424423

Abstract:

An implantable medical device, such as a stent, is disclosed. The device includes a substrate and a polymeric layer including poly(methylmethacrylate) or poly(butylmethacrylate) supported by the substrate. The polymeric layer contains rapamycin. A barrier is over at least a portion of the polymeric layer to reduce the rate of release of rapamycin from the implantable medical device. The polymeric layer can additionally include poly(ethylene co-vinyl acetate).