Cynthia B Berry

US Patent:

20220363679, Nov 17, 2022

Filed:

Mar 25, 2021

Appl. No.:

17/212274

Inventors:

- Beerse, BE
Cynthia B. Berry - Poway CA, US
Krisztián Biró - Budapest, HU
Andrew V. Samant - Cardiff CA, US
Warren S. Wade - San Diego CA, US

International Classification:

C07D 471/04
C07D 413/06
C07D 401/06
C07D 413/14
C07D 417/14

Abstract:

Aryl piperidine compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions:wherein X, R, R, R, R, Rand Rare as defined herein.

US Patent:

20210284641, Sep 16, 2021

Filed:

May 19, 2021

Appl. No.:

17/324520

Inventors:

- Beerse, BE
Cynthia G.B. Berry - San Diego CA, US
Gang Chen - San Diego CA, US
Fabrice Loic Jourdan - Olias del Rey, ES
Terry Patrick Lebold - San Diego CA, US
David Wei Lin - San Diego CA, US
Miguel Angel Pena Piñon - Olias del Rey, ES
Bradley M. Savall - San Diego CA, US
Devin M. Swanson - Carlsbad CA, US
Dongpei Wu - San Diego CA, US
Wei Zhang - San Diego CA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 471/04
C07D 471/14
A61P 25/00

Abstract:

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof,Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).

US Patent:

20210253565, Aug 19, 2021

Filed:

Feb 9, 2021

Appl. No.:

17/171559

Inventors:

- Beerse, BE
Cynthia B. Berry - San Diego CA, US
Brian Ngo Laforteza - San Diego CA, US
Jimmy T. Liang - San Diego CA, US

International Classification:

C07D 413/14
C07D 413/06
C07D 401/06
C07D 403/06

Abstract:

3.1.0 and 4.1.0 Azabicycle compounds of Formula (I), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions.wherein X, Y, R, R, and Rare defined herein.