Cynthia Cobb Adams

US Patent:

7235353, Jun 26, 2007

Filed:

Jul 18, 2003

Appl. No.:

10/623486

Inventors:

Larry C. Mattheakis - Cupertino CA, US
Jay Kenneth Trautman - Los Altos CA, US
Gregg Peter Solar - San Anselmo CA, US
Jinhong Fan - San Mateo CA, US
Eugeni Vaisberg - Foster City CA, US
Cynthia Lynn Adams - San Carlos CA, US
Aibing Rao - Burlingame CA, US

Assignee:

Cytokinetics, Inc. - South San Francisco CA

International Classification:

C12Q 3/00
C12Q 1/68
C12Q 1/26
C12Q 1/04
C12N 5/00

US Classification:

435 3, 435 6, 435 25, 435 34, 435 405, 435325, 435370, 435455

Abstract:

Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e. g. , apoptosis, necrosis, cholestasis, and/or steatosis.

US Patent:

7817840, Oct 19, 2010

Filed:

Mar 13, 2006

Appl. No.:

11/375541

Inventors:

Larry C. Mattheakis - Cupertino CA, US
Jay Kenneth Trautman - Los Altos CA, US
Gregg Peter Solar - San Anselmo CA, US
Jinhong Fan - San Mateo CA, US
Eugeni Vaisberg - Foster City CA, US
Cynthia Lynn Adams - San Carlos CA, US
Aibing Rao - Burlingame CA, US

Assignee:

Cytokinetics, Inc. - South San Francisco CA

International Classification:

G06K 9/00
G06K 9/36
G01N 1/30
C12Q 1/44

US Classification:

382133, 435 405, 435 19

Abstract:

Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e. g. , apoptosis, necrosis, cholestasis, and/or steatosis.

US Patent:

20030228565, Dec 11, 2003

Filed:

Feb 20, 2001

Appl. No.:

09/790214

Inventors:

Donald Oestreicher - Cupertino CA, US
James Sabry - San Francisco CA, US
Cynthia Adams - Berkeley CA, US
Eugeni Vaisberg - Foster City CA, US
Anne Crompton - San Francisco CA, US

Assignee:

Cytokinetics, Inc.

International Classification:

C12Q001/00
C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/004000, 435/006000, 702/019000, 702/020000

Abstract:

Techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. A method according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a multiple biological descriptors derived from a single cell component or marker. The method employs image analysis to extract a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database.

US Patent:

20050014217, Jan 20, 2005

Filed:

Nov 20, 2003

Appl. No.:

10/719988

Inventors:

Larry Mattheakis - Cupertino CA, US
Jay Trautman - Los Altos CA, US
Gregg Solar - San Anselmo CA, US
Jinhong Fan - San Mateo CA, US
Eugeni Vaisberg - Foster City CA, US
Cynthia Adams - San Carlos CA, US
Aibing Rao - Burlingame CA, US

International Classification:

G01N001/30
G01N033/48

US Classification:

435040500

Abstract:

Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.

US Patent:

20050282208, Dec 22, 2005

Filed:

Jun 16, 2005

Appl. No.:

11/155934

Inventors:

Cynthia Adams - San Carlos CA, US
Reginald de la Rosa - Concord CA, US
Shyamlal Ramchandani - San Francisco CA, US

International Classification:

C12Q001/68
G06F019/00

US Classification:

435006000, 435455000, 435325000, 702020000

Abstract:

Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may be characterized by at least the following features: (a) chromosomes that approach metaphase but fail to separate and maintain alignment compared to a control cell or cell population; (b) a bipolar spindle that is at least about 10% longer than a corresponding metaphase mitotic spindle from the control cell or cell population; and (c) during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.

US Patent:

20060228695, Oct 12, 2006

Filed:

Mar 13, 2006

Appl. No.:

11/375597

Inventors:

Larry Mattheakis - Cupertino CA, US
Jay Trautman - Los Altos CA, US
Gregg Solar - San Anselmo CA, US
Jinhong Fan - San Mateo CA, US
Eugeni Vaisberg - Foster City CA, US
Cynthia Adams - San Carlos CA, US
Aibing Rao - Burlingame CA, US

International Classification:

C12Q 1/00
G06F 19/00

US Classification:

435004000, 702019000

Abstract:

Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.

US Patent:

20070082327, Apr 12, 2007

Filed:

Sep 8, 2006

Appl. No.:

11/518500

Inventors:

Cynthia Adams - San Carlos CA, US
Reginald de la Rosa - Concord CA, US
Shyamlal Ramchandani - San Fracisco CA, US
Penelope Chua - San Francisco CA, US

International Classification:

C12Q 1/00
G01N 33/574
G06F 19/00
C12N 5/06

US Classification:

435004000, 435007230, 435325000, 702019000

Abstract:

Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may be characterized by at least the following features: mitotic arrest characterized (i) chromosomes well-aligned at the metaphase plate and (ii) chromosome residence time at the metaphase plate substantially longer than that of a control cell or cell population. The phenotype may be further characterized by: during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.