H. Horvitz - Auburndale MA, US Craig Ceol - Roslindale MA, US Erik Andersen - Somerville MA, US
International Classification:
C12Q001/68 G01N033/574
US Classification:
435006000, 435007230
Abstract:
In general, the invention provides methods and compositions useful in the treatment of a neoplasia. These compositions include new components of the Rb pathway that function in chromatin remodeling and antagonize Ras signaling.
Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an inhibitor of SETDB1 to a subject in need thereof.
H ROBERT HORVITZ - AUBURNDALE MA, US CRAIG CEOL - SOMERVILLE MA, US XIAOWEI LU - ARLINGTON MA, US
International Classification:
A61K038/43
US Classification:
424/094100
Abstract:
The invention provides novel genes involved in cell fate and cell proliferation, including lin-37, lin-35, lin-53, lin-55, lin-52, and lin-54 in multiple species and an E2F-1 gene of Methods for utilizing the genes and encoded proteins are also provided.
- Boston MA, US Craig Ceol - Sherborn MA, US Yariv J. Houvras - New York NY, US
Assignee:
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
G01N 33/574 C12Q 1/68 A61K 39/395
Abstract:
Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an inhibitor of SETDB1 to a subject in need thereof.
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