Cory Gene Acuff

US Patent:

20110274651, Nov 10, 2011

Filed:

Sep 4, 2009

Appl. No.:

13/061447

Inventors:

Cory Acuff - Lawrenceville GA, US
Daniel Kalman - Atlanta GA, US

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 31/4355
A61K 31/5377
A61K 31/4725
A61K 31/506
A61K 39/395
A61K 31/7088
A61K 31/7105
A61K 38/21
A61K 31/7028
A61K 31/4353
A61K 31/407
A61K 31/545
A61K 38/02
A61K 31/397
A61K 31/43
A61K 31/65
A61K 31/7048
A61K 31/513
A61P 31/00
A61P 31/14
A61P 31/12
A61P 31/20
A61P 31/22
A61P 31/16
A61P 31/18
A61P 31/04
A61P 31/10
A61K 31/496

US Classification:

424 854, 514291, 51425303, 5142328, 514256, 4241311, 514 44 A, 514 44 R, 514 25, 51421004, 51421009, 514200, 514 31, 51421002, 514192, 514154, 514 24, 514 31, 51425407, 514274

Abstract:

Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are disclosed. The compositions include various noscapine analogs, which are capable of blocking the movement of viruses and other microbes within mammalian and other cells by inhibiting the cytoplasmic transport mechanisms within the cells. The compositions described herein include an effective amount of the noscapine analogues described herein, along with a pharmaceutically acceptable carrier or excipient. The compositions can also include one or more additional antimicrobial compounds.