Cortino Sukotjo

US Patent:

7365175, Apr 29, 2008

Filed:

Jun 12, 2002

Appl. No.:

10/170786

Inventors:

Ichiro Nishimura - Los Angles CA, US
Cortino Sukotjo - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07H 21/02
C07H 21/04
A61K 38/00

US Classification:

536 231, 435 691, 435325, 4352533, 514 44

Abstract:

The present invention provides a method of treatment to improve wound healing and to minimize/prevent abnormal scarring caused by tissue contraction and fibrosis formation by providing a specific gene, Wit 3. 0 alpha and beta sequences that is differentially expressed in wounded oral mucosa cells, relative to their decreased expression in non-wounded oral mucosa cells. One aspect of the invention is a method to treat soft tissue wound using anti-sense nucleic acid technologies. Another aspect of the present invention is a method to treat soft tissue wound using sense nucleic acid technologies. These methods can employ a complimentary nucleic acid sequence that is greater than 85% identity to Wit 3. 0 alpha and/or beta sequences or greater than 90% identity to the deduced amino acids thereof.