Collin James Weber

US Patent:

7041634, May 9, 2006

Filed:

Mar 27, 1998

Appl. No.:

09/049865

Inventors:

Collin J. Weber - Atlanta GA, US
Mary K. Hagler - Loganville GA, US
Peter S. Linsley - Seattle WA, US
Judith A. Kapp - Atlanta GA, US
Susan A. Safley - Decatur GA, US

Assignee:

Emory University - Atlanta GA
Bristol Myers-Squibb Company - New York NY

International Classification:

A61K 38/00

US Classification:

514 2, 4241561, 4241371, 4241411, 424 937, 424812, 530350

Abstract:

This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a device comprising a semipermeable membrane; and b) treating the subject with a substance which inhibits an immune-system costimulation event in an amount effective to inhibit the subject's immune system from responding to said contained cells or tissue. In one embodiment, the substance which inhibits an immune-system costimulation event is CTLA4. Also provided by this invention is a method of treating diabetes in a subject which comprises: a) containing viable insulin-producing cells, or tissue comprising such cells, within a device comprising a semipermeable membrane; b) transplanting an effective amount of such contained viable insulin-producing cells into the subject; and c) treating the subject with an effective amount of a substance which inhibits an immune-system costimulation event.

US Patent:

57955700, Aug 18, 1998

Filed:

Apr 7, 1995

Appl. No.:

8/418953

Inventors:

Collin J. Weber - Atlanta GA

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 3512
C12N 1110
B01J 1320

US Classification:

424 937

Abstract:

A core material such as animal tissue or cells is contained within a semipermeable vessel which may be a microcapsule, hollow fiber or plastic membrane having a semipermeable wall by a method that prevents the core material from incorporation into the wall of the vessel. This is accomplished by suspending the core material in a solution of polysaccharide gum such as an alkali metal alginate in an amount between about 0. 2% and about 0. 5%, removing and washing the core material to remove all but a thin layer of polysaccharide gum, and gelling the polysaccharide gum with multivalent cations or other means to form a pretreated core material. The pretreated core material is contained within a semipermeable vessel such as by suspending the pretreated core material in a solution of alkali metal alginate, forming the suspension into droplets, gelling the droplets to form temporary shape-retaining capsules and treating the capsules with a polymeric material having groups that react with and crosslink acid groups of the capsules to form a permanent semipermeable membrane around the capsules. A second permanent semipermeable membrane may be formed around the capsules to form double-walled microcapsules by further treating the capsules with the polymeric material. The semipermeable vessel may be impermeable to immune factors.

US Patent:

52272982, Jul 13, 1993

Filed:

Aug 17, 1990

Appl. No.:

7/568821

Inventors:

Collin J. Weber - Leonia NJ
Janet E. Norton - Scranton PA
Keith Reemtsma - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 1110
C12N 1104

US Classification:

435178

Abstract:

The subject invention provides a method of encapsulating viable tissue or cells within a double walled bead, the double-walled bean produced as a result of the method, as well as a method of pretreating the tissue or cells with an immunosuppressant such as UV-B irradiation prior to their encapsulation.

US Patent:

20150174273, Jun 25, 2015

Filed:

Jul 24, 2013

Appl. No.:

14/416694

Inventors:

- Atlanta GA, US
Collin J. Weber - Atlanta GA, US

Assignee:

EMORY UNIVERSITY - Atlanta GA

International Classification:

A61K 51/04

Abstract:

It has been discovered that human parathyroid tumor cells express high densities of folate receptors which could provide a target that may be used for localization. In certain embodiments, the disclosure relates to methods of detecting and imaging parathyroid tumors or canccrous cells in tissues using a folatc conjugate to enhance imaging techniques such as magnetic resonance imaging, positron emission tomography, computed tomography (CT), and single-photon emission computed tomography (SPECT). An image of radioactivities or nuclear magnetic resonance frequencies as a function of location for parcels (voxels), may be constructed and plotted. The image shows the tissues in which the tracer has become concentrated.

US Patent:

20140105974, Apr 17, 2014

Filed:

Mar 14, 2012

Appl. No.:

14/000471

Inventors:

Collin J. Weber - Atlanta GA, US
Susan A. Safley - Decatur GA, US
Kereen S. Gordon - Alpharetta GA, US
Nicholas E. Simpson - Alachua FL, US

Assignee:

EMORY UNIVERSITY - Atlanta GA

International Classification:

A61K 9/48
A61K 35/39

US Classification:

424463, 424 937, 4241781

Abstract:

This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments the disclosure relates to capsules comprising a cell or cells gelled in alginate coated with a layer that prevents migration of immune molecules to the cell surface and an outer capsule layer comprising non-immunogenic material optionally containing immunosuppressive agents. In certain embodiments, the cells are capable of generating insulin that emanates from the capsule.