Clinton L White

Author:

Clinton E. White

ISBN #:

0894135880

US Patent:

7309232, Dec 18, 2007

Filed:

Oct 10, 2003

Appl. No.:

10/684226

Inventors:

Bruce Rutherford - Seattle WA, US
Christopher Somogyi - Woodinville WA, US
Clinton White - Raleigh NC, US
Erick Rabins - Seattle WA, US

Assignee:

Dentigenix Inc. - Seattle WA

International Classification:

A61C 5/04
A61B 19/02

US Classification:

433226, 206 635

Abstract:

The invention provides methods, apparatus and kits for regenerating dental tissue in vivo that are useful for treating a variety of dental conditions, exemplified by treatment of caries. The invention uses tissue scaffold wafers, preferably made of PGA, PLLA, PDLLA or PLGA dimensioned to fit into a hole of corresponding sized drilled into the tooth of subject to expose dental pulp in vivo. In certain embodiments the tissue scaffold wafer further comprises calcium phosphate and fluoride. The tissue scaffold wafer may be secured into the hole with a hydrogel, a cement or other suitable material. Either the wafer or the hydrogel or both contain a morphogenic agent, such as a member encoded by the TGF-β supergene family, that promotes regeneration and differentiation of healthy dental tissue in vivo, which in turn leads to remineralization of dentin and enamel. The tissue scaffold may further include an antibiotic or anti-inflammatory agent.

US Patent:

20070248933, Oct 25, 2007

Filed:

Mar 23, 2007

Appl. No.:

11/728015

Inventors:

Bruce Rutherford - Seattle WA, US
Christopher Somogyi - Woodinville WA, US
Clinton White - Raleigh NC, US
Erick Rabins - Seattle WA, US

Assignee:

Dentigenix Inc. - Seattle WA

International Classification:

A61C 17/12
A61C 3/00
A61C 5/04
A61C 8/00
A61F 2/28
A61K 8/21
A61Q 11/00

US Classification:

433092000, 424423000, 424052000, 433163000, 433226000

Abstract:

The invention provides methods, apparatus and kits for regenerating dental tissue in vivo that are useful for treating a variety of dental conditions, exemplified by treatment of caries. The invention uses tissue scaffold wafers, preferably made of PGA, PLLA, PDLLA or PLGA dimensioned to fit into a hole of corresponding sized drilled into the tooth of subject to expose dental pulp in vivo. In certain embodiments the tissue scaffold wafer further comprises calcium phosphate and fluoride. The tissue scaffold wafer may be secured into the hole with a hydrogel, a cement or other suitable material. Either the wafer or the hydrogel or both contain a morphogenic agent, such as a member encoded by the TGF-β supergene family, that promotes regeneration and differentiation of healthy dental tissue in vivo, which in turn leads to remineralization of dentin and enamel. The tissue scaffold may further include an antibiotic or anti-inflammatory agent.