Claudia Fischbach

US Patent:

20100056390, Mar 4, 2010

Filed:

Jul 28, 2009

Appl. No.:

12/510925

Inventors:

Claudia Fischbach - Ithaca NY, US

International Classification:

C40B 30/06
C12N 5/00
C40B 60/00
C12Q 1/02

US Classification:

506 10, 435325, 506 33, 435 29

Abstract:

A three-dimensional cell culture system is provided comprising one or more cell types of interest incorporated in a natural or synthetic hydrogel. An apparatus for high-throughput drug screening is also provided comprising a plurality of three-dimensional cell culture systems and a dispenser for placing at least one three-dimensional cell culture system into a pre-determined well of a multiwell plate. A method for high-throughput drug screening is also provided that comprises providing a test agent, providing a three-dimensional cell culture system, determining a first cellular response of the cell of interest before culturing in the presence of the agent, culturing the cell of interest in the cell culture system in the presence of the agent, determining a second cellular response of the cell of interest after culturing in the presence of the agent, and comparing the first and second cellular responses.