Clark K Colton from Los Angeles, CA, age 83

License Records

Clark K Colton

Address:

Chestnut Hill, MA 02467

License #:

25960 - Expired

Issued Date:

Jan 14, 1972

Expiration Date:

Jun 30, 2010

Type:

Chemical Engineer

Resumes

Professor Department Of Chemical Engi

view source

Location:

279 Commonwealth Ave, Norfolk, MA

Industry:

Higher Education

Work:

Massachusetts Institute of Technology (Mit)
Professor Department of Chemical Engi

Education:

Massachusetts Institute of Technology 1964 - 1969
Doctorates, Doctor of Philosophy, Chemical Engineering, Philosophy Cornell University 1959 - 1964

Skills:

Data Analysis
Molecular Biology
Research
Science
Analysis
Matlab
Start Ups
Biotechnology
R&D
Materials Science
Strategy
Statistics
Lifesciences
Teaching
Cell Culture
Entrepreneurship
Life Sciences

Us Patents

Method Of Delivering Oxygen To Cells By Electrolyzing Water
view source
US Patent:

6368592, Apr 9, 2002
Filed:

Jul 16, 1999
Appl. No.:

09/356079
Inventors:

Clark K. Colton - Newton MA
Larry L. Swette - Newton MA
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

C12N 504
US Classification:

424 937, 424423, 435325, 435382, 435383, 4352891, 4352971
Abstract:

Oxygen is supplied to cells in vitro or in vivo by generating oxygen with an oxygen generator that electrolyzes water to oxygen and hydrogen. Oxygen can be generated substantially without generating free hydrogen using a multilayer electrolyzer sheet having a proton exchange membrane sandwiched by an anode layer and a cathode layer. The oxygen generator may be used to supply oxygen to cells contained by a culture plate, a culture flask, a microtiter plate or an extracorporeal circuit, or to cells in an encapsulating chamber for implanting in the body such as an immunoisolation chamber bounded by a semipermeable barrier layer that allows selected components to enter and leave the chamber. A bioactive molecule may be present with the cells. Oxygen can be delivered in situ to cells within the body such as by implanting the oxygen generator in proximity to cell-containing microcapsules in an intraperitoneal space, or by implanting a system containing the oxygen generator in proximity to an immunoisolation chamber containing cells.

System And Method For Ultrasonic Measuring Of Particle Properties
view source
US Patent:

7543480, Jun 9, 2009
Filed:

Nov 14, 2005
Appl. No.:

11/272032
Inventors:

Steven A. Africk - Waban MA, US
Clark K. Colton - Newton MA, US
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

G01N 11/10
US Classification:

73 5425, 600440, 73 5301, 73 5424, 73 6166, 73 6171
Abstract:

Devices, systems and methods for measuring and detecting properties of a variety of particles or cells in suspension. Properties, such as, for example, velocity of particles, concentration and/or size may be measured according to the methods of the invention. Acoustic energy may be introduced to a focal zone and narrow band interrogating signals may be used. The acoustic energy may cause movement or streaming of the fluid or suspension. The acoustic streaming may allow a Doppler effect measurement without any other source of velocity.

System And Method For Ultrasonic Measuring Of Particle Properties
view source
US Patent:

7984642, Jul 26, 2011
Filed:

Jun 9, 2009
Appl. No.:

12/481324
Inventors:

Steven A. Africk - Waban MA, US
Clark K. Colton - Newton MA, US
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

G01N 11/10
US Classification:

73 5425, 600440, 73 5301, 73 5424, 73 6166, 73 6171
Abstract:

Devices, systems and methods for measuring and detecting properties of a variety of particles or cells in suspension. Properties, such as, for example, velocity of particles, concentration and/or size may be measured according to the methods of the invention. Acoustic energy may be introduced to a focal zone and narrow band interrogating signals may be used. The acoustic energy may cause movement or streaming of the fluid or suspension. The acoustic streaming may allow a Doppler effect measurement without any other source of velocity.

Amphiphilic Polymers And Methods Of Use Thereof
view source
US Patent:

8349991, Jan 8, 2013
Filed:

Apr 17, 2006
Appl. No.:

11/405012
Inventors:

Clark K. Colton - Newton MA, US
Arthur Watterson - Nashua NH, US
Rajesh Kumar - Dract MA, US
Virinder S. Parmar - Lowell MA, US
Robert Fisher - West Roxbury MA, US
Jayant Kumar - Westford MA, US
Assignee:

Massachusetts Institute of Technology - Cambridge MA
University of Massachusetts Lowell - Lowell MA
International Classification:

C08G 63/06
C08G 63/12
C08G 69/08
C08G 75/00
C08G 63/00
C08G 67/00
C08G 69/00
A61K 47/30
US Classification:

528209, 528331, 528172, 528271, 528272, 5147723
Abstract:

The present invention relates to amphiphilic polymers, and micelles and compositions comprising the same, and their use in a variety of biological settings, including imaging, targeting drugs, or a combination thereof for diagnostic and therapeutic purposes.

Method And Apparatus For Delivering Oxygen To Cells
view source
US Patent:

20030087427, May 8, 2003
Filed:

Oct 24, 2001
Appl. No.:

10/040278
Inventors:

Clark Colton - Newton MA, US
Larry Swette - Newton MA, US
International Classification:

C12M001/00
C12M003/00
US Classification:

435/289100
Abstract:

An apparatus and method to enhance oxygen delivery to tissue encapsulated in an immunobarrier device. In one embodiment, in situ electrochemical oxygen generation by electrolysis of water into oxygen and hydrogen supplies oxygen to the tissue. In one embodiment a thin, multilayer sheet electrolyzer is enclosed in silicone rubber membranes permeable to gas and water vapor but not liquids. The anode side of the electrolyzer is in contact with one face of the device. Water vapor diffuses into the electrolyzer, decomposes at the anode, and oxygen diffuses back through the membrane to the implanted tissue, thus providing a continuous supply of water, continuous diffusion of Oand Hout of the electrolyzer, and exclusion of biological components that might contaminate the electrolyzer.

Methods And Compositions For Enhanced Differentiation From Embryonic Stem Cells
view source
US Patent:

20100261277, Oct 14, 2010
Filed:

Jun 13, 2008
Appl. No.:

12/664763
Inventors:

Clark K. Colton - Newton MA, US
Daryl Powers - Cambridge MA, US
Jeffrey R. Millman - Cambridge MA, US
Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - CAMBRIDGE
International Classification:

C12N 5/02
US Classification:

435377
Abstract:

The invention provides methods for differentiating pluripotent stem cells such as ES cells with improved progenitor and differentiated cell yield using low oxygen conditions and optionally in the absence of exogenously added differentiation factors.

Encapsulated Pancreatic Islet Cell Products And Methods Of Use Thereof
view source
US Patent:

20110045077, Feb 24, 2011
Filed:

Nov 13, 2007
Appl. No.:

12/514753
Inventors:

Gordon Weir - Cambridge MA, US
Clark K. Colton - Newton MA, US
Esther O'Sullivan - Dublin, IE
Amy Lewis - Cambridge MA, US
International Classification:

A61K 9/14
A61K 35/39
A61P 3/10
A61P 3/08
A61P 1/18
US Classification:

424488, 424484, 424 937
Abstract:

This invention is directed, inter alia, to encapsulated cell products, compositions comprising the same and uses thereof to treat diabetes, and related complications, increase islet cell masses, improve a metabolic profile in a subject, and other related conditions. Processes to produce the encapsulated islet cell product are described.

Graft Systems Having Semi-Permeable Filling Structures And Methods For Their Use
view source
US Patent:

20120203264, Aug 9, 2012
Filed:

Jan 23, 2012
Appl. No.:

13/355705
Inventors:

Anupama Karwa - San Francisco CA, US
Raj P. Ganpath - Sunnyvale CA, US
Clark K. Colton - Newton MA, US
Assignee:

Endologix, Inc. - Irvine CA
International Classification:

A61M 29/00
US Classification:

606194
Abstract:

Aneurysms are treated by filling at least one double-walled filling structure with a filling medium within the aneurysm, such as filling structures having a membrane that allows water molecules to permeate across the membrane in response to a water potential differential across the membrane. The transport of fluid across the membrane allows the bag to expand or shrink to accommodate changes in the size or shape of the aneurysm, thereby maintaining a seal between the filling structure against the vessel wall and maintaining apposition of the filling structure against the inside surface of the aneurysm. Transport of water molecules into or out of the filling structure is controlled by adjusting for the osmolarity of the filling fluid medium. The filling structures may be delivered over balloon deployment mechanisms in order to shape occlude the aneurysm and open a tubular lumen for flow of blood through the filling structure.