Christopher J Velis

US Patent:

20230054472, Feb 23, 2023

Filed:

Dec 23, 2020

Appl. No.:

17/788137

Inventors:

- Cambridge MA, US
Nisha Veronica VARMA - Brookline MA, US
Gregory T. MARTIN - Boston MA, US
Goossen Jan Bernard BOER - Brookline MA, US
Zhiqian ZHOU - Boston MA, US
Christopher VELIS - Lexington MA, US

Assignee:

Miraki Innovation Think Tank LLC - Cambridge MA

International Classification:

G01N 33/569
G01N 33/543
G01N 33/68

Abstract:

Methods are described for preparing samples including biological, environmental, and food products for microbial analysis. Microbes and microbe components in the sample can be treated with antimicrobial compounds and a matrix solution to permit fast and accurate characterization using analysis techniques such as matrix-assisted laser desorption/ionization Time-of-Flight mass spectrometry (MALDI-TOF MS).

US Patent:

20230000671, Jan 5, 2023

Filed:

Sep 8, 2022

Appl. No.:

17/940681

Inventors:

- Cambridge MA, US
Christopher VELIS - Cambridge MA, US

Assignee:

MIRAKI INNOVATION THINK TANK LLC - Cambridge MA

International Classification:

A61F 7/12
A61M 25/10
A61M 25/00

Abstract:

The present invention provides methods and devices for controlling a cold slurry that is delivered to a target tissue and for limiting heat transferring from surrounding tissue to the target tissue. In particular, a balloon structure is deployed at or near a point of delivery to act as a physical and/or thermal barrier. In some instances, the balloon structure can act as a pressure device obstructing the flow of warm blood into a treatment area, which can melt the cold slurry.

US Patent:

20200086054, Mar 19, 2020

Filed:

Nov 25, 2019

Appl. No.:

16/694346

Inventors:

- Cambridge MA, US
Christopher J.P. Velis - Lexington MA, US

International Classification:

A61M 5/31
A61M 5/315

Abstract:

A cold slurry syringe with enhanced features is provided for delivering a cold slurry into the human body. The syringe includes a syringe body for holding a volume of cold slurry, a plunger that slides within the syringe body for ejecting the cold slurry, and a tapered syringe head for delivering an even flow of cold slurry. An agitator can be added to keep the cold slurry from agglomerating and clogging the syringe. Insulation added around the syringe can keep the cold slurry from melting too quickly. A ball screw drive can be added to provide a smooth and consistent application of pressure as the cold slurry is delivered. The cold slurry flow can be enhanced by adding a streamline flow feature that reduces the occurrence of eddies or swirls inside the syringe. This feature can also help maintain the composition and consistency of the cold slurry.

US Patent:

20190054242, Feb 21, 2019

Filed:

Aug 21, 2017

Appl. No.:

15/682234

Inventors:

Christopher J.P. Velis - Cambridge MA, US

International Classification:

A61M 5/31
A61M 5/315

Abstract:

A cold slurry syringe with enhanced features is provided for delivering a cold slurry into the human body. The syringe includes a syringe body for holding a volume of cold slurry, a plunger that slides within the syringe body for ejecting the cold slurry, and a tapered syringe head for delivering an even flow of cold slurry. An agitator can be added to keep the cold slurry from agglomerating and clogging the syringe. Insulation added around the syringe can keep the cold slurry from melting too quickly. A ball screw drive can be added to provide a smooth and consistent application of pressure as the cold slurry is delivered. The cold slurry flow can be enhanced by adding a streamline flow feature that reduces the occurrence of eddies or swirls inside the syringe. This feature can also help maintain the composition and consistency of the cold slurry.

US Patent:

20180289537, Oct 11, 2018

Filed:

Apr 5, 2018

Appl. No.:

15/946410

Inventors:

- Cambridge MA, US
Christopher J.P. Velis - Cambridge MA, US

International Classification:

A61F 7/12
A61K 9/00
A61K 47/02
A61F 7/00

Abstract:

The present invention provides methods and devices for making a cold slurry at a point of delivery. A point of delivery device delivers cold slurry components to a location at or near a target tissue. The components are combined to form the cold slurry at or near the point of delivery. This approach to generating a cold slurry at the point of delivery allows the characteristics of the cold slurry, such as temperature, particle shape and particle size, to be maintained and controlled.

US Patent:

20180289538, Oct 11, 2018

Filed:

Apr 5, 2018

Appl. No.:

15/946474

Inventors:

- Cambridge MA, US
Christopher J.P. Velis - Cambridge MA, US

International Classification:

A61F 7/12
A61M 25/10
A61M 25/00

Abstract:

The present invention provides methods and devices for controlling a cold slurry that is delivered to a target tissue and for limiting heat transferring from surrounding tissue to the target tissue. In particular, a balloon structure is deployed at or near a point of delivery to act as a physical and/or thermal barrier. In some instances, the balloon structure can act as a pressure device obstructing the flow of warm blood into a treatment area, which can melt the cold slurry.

US Patent:

20180140514, May 24, 2018

Filed:

Aug 21, 2017

Appl. No.:

15/682272

Inventors:

Christopher J.P. Velis - Cambridge MA, US
Karen Miller - Cambridge MA, US

International Classification:

A61K 8/04
A61K 8/19
A61K 8/34
A61M 5/19
A61M 5/315
A61M 5/44
A61M 5/46
A61Q 19/08

Abstract:

The present invention is directed to targeted delivery of a cold slurry underneath a patient's skin to improve the cosmetic appearance of the skin. The “target” tissue can be muscle tissue that when cooled cannot contract and cause wrinkles/lines in the skin to appear. The target tissue can also be adipose tissue that causes overlying tissue to sag and form wrinkles/lines. The cold slurry induces apoptosis, and reduces the size of the tissue, and causes the connective tissue supporting the skin to thicken and tighten, thereby reducing wrinkles/lines. Skin can also be tightened with cold slurry injected into the dermis layer of the skin or within the layers of the oral mucosa making a cold slurry treatment ideal for reducing the appearance of baggy skin after a patient loses weight and or for treating obstructive sleep apnea. Cold slurry can also be used to treat cellulite and acne.

US Patent:

20180116868, May 3, 2018

Filed:

Oct 31, 2017

Appl. No.:

15/798489

Inventors:

Christopher J.P. Velis - Cambridge MA, US
Cole C. Velis - Cambridge MA, US
Karen Miller - Cambridge MA, US

International Classification:

A61F 7/12
A61F 7/00

Abstract:

The present invention involves the use of a small profile device for preparation and/or delivery of cold slurry into the human body. The cold slurry can be generated within the device itself or within a separate small chamber, both of which produce a cold slurry using a cooling source and an injectable fluid. The delivery device provides continued agitation to the fluid/slurry through rotation and/or vibration of blades within the device. The fluid/cold slurry is cooled/kept cool through the use of an external cooling device, such as a cooling sleeve, that at least partially surrounds the delivery device. The cooling sleeve can cool or maintain the temperature of the cold slurry through a number of mechanisms. The cold slurry can be delivered using a device in accordance with the present invention to any tissue inside the body, including subcutaneous fat, visceral fat, and brown fat.