Brian F. Volkman - Muskego WI, US Christopher T. Veldkamp - Milwaukee WI, US Francis C. Peterson - Racine WI, US Thomas Sakmar - New York NY, US Christoph H. Seibert - Frankfurt am Main, DE
Assignee:
Medical College of Wisconsin Research Foundation - Milwaukee WI The Rockefeller University - New York NY
International Classification:
A61K 38/00
US Classification:
514 193, 514 189, 514 196, 514 198, 514 11
Abstract:
The present invention provides a novel CXCL12-αlocked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.
Brian F. Volkman - Muskego WI, US Christopher T. Veldkamp - Milwaukee WI, US Francis C. Peterson - Racine WI, US Thomas Sakmar - New York NY, US Christoph H. Seibert - Frankfurt am Main, DE
Assignee:
Medical College of Wisconsin Research Foundation - Milwaukee WI
International Classification:
A61K 38/17 C07K 14/435
US Classification:
514 12, 530324
Abstract:
The present invention provides a novel CXCL12-αlocked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.
Brian F. Volkman - Muskego WI, US Christopher T. Veldkamp - Milwaukee WI, US Francis C. Peterson - Racine WI, US Thomas Sakmar - New York NY, US Christoph H. Seibert - Frankfurt am Main, DE
Assignee:
The Rockefeller University - New York NY Medical College of Wisconsin Research Foundation - Milwaukee WI
International Classification:
C07K 14/52
US Classification:
514 38
Abstract:
The present invention provides a novel CXCL12-αlocked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.
- Milwaukee WI, US Joshua Ziarek - Boston MA, US Christopher Veldkamp - Milwaukee WI, US Francis Peterson - Racine WI, US
Assignee:
The Medical College of Wisconsin, Inc. - Milwaukee WI
International Classification:
A61K 38/19 C07K 14/52
Abstract:
The present invention provides a CXCL12peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.
- Milwaukee WI, US Joshua Ziarek - Boston MA, US Christopher Veldkamp - Milwaukee WI, US Francis Peterson - Racine WI, US
International Classification:
C07K 14/52 A61K 38/00
Abstract:
The present invention provides a CXCL12peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.
Monomeric Cxcl121 Peptide And Methods Of Synthesis And Use Thereof
- Milwaukee WI, US Joshua Ziarek - Boston MA, US Christopher Veldkamp - Milwaukee WI, US Francis Peterson - Racine WI, US
International Classification:
C07K 14/52
Abstract:
The present invention provides a CXCL12peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.