Christian J Kastrup from Mequon, WI, age 45

Us Patents

Stochastic Confinement To Detect, Manipulate, And Utilize Molecules And Organisms
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US Patent:

20100227767, Sep 9, 2010
Filed:

Jul 28, 2008
Appl. No.:

12/670739
Inventors:

James Q. Boedicker - Chicago IL, US
Rustem F. Ismagilov - Chicago IL, US
Christian Kastrup - Cambridge MA, US
Cory Gerdts - Romeoville IL, US
Toan Huynh - Chicago IL, US
Hyun Jung Kim - Chicago IL, US
Matthew K. Runyon - Chicago IL, US
Feng Shen - Chicago IL, US
International Classification:

C40B 30/00
C12Q 1/02
C12Q 1/18
US Classification:

506 7, 435 29, 435 32
Abstract:

Methods of detecting organisms e.g. bacteria using stochastic confinement effects with microfluidic technologies involving plugs are provided. Signal amplification methods for the detection of molecules are also disclosed.

Substrates And Methods For Culturing Stem Cells
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US Patent:

20100273259, Oct 28, 2010
Filed:

Apr 22, 2010
Appl. No.:

12/765472
Inventors:

Krishanu Saha - Cambridge MA, US
Ying Mei - Cambridge MA, US
Said R. Bogatyrev - Cambridge MA, US
Daniel G. Anderson - Sudbury MA, US
Rudolf Jaenisch - Brookline MA, US
Robert S. Langer - Newton MA, US
Morgan Alexander - Nottingham, GB
Martyn Davies - Nottingham, GB
Jing Yang - Nottingham, GB
Christian J. Kastrup - Cambridge MA, US
Andrew Urquhart - Glasgow, GB
Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:

C12N 5/0797
US Classification:

435377, 435395, 435396
Abstract:

The present disclosure provides a device and a cell culture system comprising a substrate that generates significant chemical ion signatures adapted for culturing stem cells. This disclosure further provides unique surface properties, such as surface wettability, along with defined polymer microspot environments in an array, for effectively supporting the propagation and differentiation of human pluripotent stem cells in vitro. Methods of culturing, maintenance, differentiating stem cells as well as reprogramming somatic cells into stem cells using the device and the cell culture system with the suitable substrates, along with suitable culture media, are also provided.

Compositions And Methods For The Treatment Of Atherosclerosis And Other Related Diseases
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US Patent:

20110077216, Mar 31, 2011
Filed:

Sep 30, 2010
Appl. No.:

12/895278
Inventors:

Christian Kastrup - Waltham MA, US
Daniel Griffith Anderson - Sudbury MA, US
Robert S. Langer - Newton MA, US
Haeshin Lee - Daejeon, KR
Matthias Nahrendorf - Charlestown MA, US
Ralph Weissleder - W. Peabody MA, US
Jose Luiz Figueiredo - Brookline MA, US
Assignee:

Massachusetts Institute of Technology - Cambridge MA
The General Hospital Corporation d/b/a Massachusetts General Hospital - Boston MA
International Classification:

A61K 31/728
A61P 9/10
C08B 37/04
A61K 31/734
C07C 237/20
A61K 31/165
US Classification:

514 54, 5361231, 536 187, 564153, 514616
Abstract:

The present invention provides compositions and methods for the treatment of atherosclerosis and other related diseases. In some embodiments, a method comprises providing a composition and forming a coating of the composition on at least a portion of the interior and/or exterior surface of a tissue lumen or other body surface. The composition may remain associated with the tissue lumen or other body surface even in the presence of a strong flow of a fluid (e.g., blood flow in a blood vessel). The composition may associate with the tissue lumen via a plurality of covalent bonds. In some cases, the compositions may comprise at least one additive, for example, a therapeutically active agent or an imaging agent.

Method And Apparatus For Assaying Blood Clotting
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US Patent:

20090104637, Apr 23, 2009
Filed:

Jan 31, 2007
Appl. No.:

12/162763
Inventors:

Rustem F. Ismagilov - Chicago IL, US
Christian J. Kastrup - Chicago IL, US
Matthew K. Runyon - Chicago IL, US
Helen Song - Chicago IL, US
Feng Shen - Chicago IL, US
International Classification:

C12Q 1/56
C12M 1/34
US Classification:

435 13, 4352871
Abstract:

This invention provides an apparatus for assaying clotting activity. The apparatus includes an inlet for a blood fluid and two or more patches of material in the vessel. The material is capable of initiating a clotting pathway in a blood fluid. This invention also provides an apparatus for measuring clot propagation, which includes a region with material capable of initiating a clotting pathway, and a region where the clot propagation is monitored. Also provided are methods for assaying clotting activity, assaying the integrity of a blood clotting pathway, assaying the effect of a substance on the integrity of a blood clotting pathway, monitoring clot propagation, and preventing clot propagation from one vessel to another.

Resumes

Assistant Professor

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Position:

Assistant Professor at The University of British Columbia

Location:

Vancouver, British Columbia, Canada

Industry:

Biotechnology

Work:

The University of British Columbia - Michael Smith Laboratories and Dept. of Biochemistry and Molecular Biology since Aug 2011
Assistant Professor
MIT Jul 2008 - Jul 2011
Postdoctoral Fellow
Pfizer Jun 2002 - Aug 2003
Reseach Internship

Education:

University of Chicago 2003 - 2008
PhD, Chemistry University of New Hampshire 1998 - 2002
B.S., Chemistry