Amy Mae Bunker - Middletown CT Xue-Min Cheng - Ann Arbor MI Annette Marian Doherty - Paris, FR Jeremy John Edmunds - Ypsilanti MI Gerald David Kanter - West Bloomfield MI Chitase Lee - Ann Arbor MI Joseph Thomas Repine - Ann Arbor MI Richard William Skeean - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
C07D27902
US Classification:
5142265, 544 49
Abstract:
The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula I The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
Certain Benzothiazine Dioxide Endothelin Antagonists And Processes For Their Preparation
Amy Mae Bunker - Middletown CT Xue-Min Cheng - Ann Arbor MI Annette Marian Doherty - Paris, FR Jeremy John Edmunds - Ypsilanti MI Gerald David Kanter - West Bloomfield MI Chitase Lee - Ann Arbor MI Joseph Thomas Repine - Ann Arbor MI Richard William Skeean - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
C07D27916
US Classification:
544 49
Abstract:
The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
Compounds That Modulate Ppar Activity And Methods Of Preparation
Xue-Min Cheng - Ann Arbor MI Noe Erasga - Ann Arbor MI Gary Frederick Filzen - Ann Arbor MI Andrew Geyer - Novi MI Chitase Lee - Ann Arbor MI Bharat Kalidas Trivedi - Farmington Hills MI
Assignee:
Warner-Lambert Company, LLC - Morris Plains NJ
International Classification:
A61K 3142
US Classification:
514365, 514374, 548203, 548204, 548235
Abstract:
This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
Compounds That Modulate Ppar Activity And Methods Of Preparation
Xue-Min Cheng - Ann Arbor MI, US Gary F. Filzen - Ann Arbor MI, US Andrew G. Geyer - Novi MI, US Chitase Lee - Ann Arbor MI, US Bharat K. Trivedi - Farmington Hills MI, US
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K031/426 C07D277/30 A61P003/00
US Classification:
514365, 548203
Abstract:
This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
Compounds That Modulate Ppar Activity And Methods Of Preparation
Xue-Min Cheng - Ann Arbor MI, US Gary F. Filzen - Ann Arbor MI, US Andrew G. Geyer - Novi MI, US Chitase Lee - Ann Arbor MI, US Bharat K. Trivedi - Farmington Hills MI, US
Assignee:
Warner-Lambert Company, LLC - Morris Plains NJ
International Classification:
A61K 31/426 C07D 277/30
US Classification:
514365, 548203, 548202
Abstract:
This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
Compounds That Modulate Ppar Activity And Methods Of Preparation
Larry D. Bratton - Whitmore Lake MI, US Xue-Min Cheng - Ann Arbor MI, US Noe Erasga - Ann Arbor MI, US Gary F. Filzen - Ann Arbor MI, US Andrew G. Geyer - Novi MI, US Chitase Lee - Ann Arbor MI, US Bharat K. Trivedi - Farmington Hills MI, US Paul C. Unangst - Ann Arbor MI, US
This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing dyslipidemia, hypercholesterolemia, obesity, hyperglycemia, atherosclerosis, hypertriglyceridemia and hyperinsulinemia in a mammal. The present invention also relates to methods for making the disclosed compounds.
Pyrazolyl And Pyrimidinyl Tricyclic Enones As Antioxidant Inflammation Modulators
Eric Anderson - Southlake TX, US Gary L. Bolton - Ann Arbor MI, US Bradley Caprathe - Livonia MI, US Xin Jiang - Coppell TX, US Chitase Lee - Ann Arbor MI, US William H. Roark - Ann Arbor MI, US Melean Visnick - Irving TX, US
Amy Bunker - Middletown CT, US Xue-Min Cheng - Ann Arbor MI, US Annette Doherty - Paris, FR Jeremy Edmunds - Ypsilanti MI, US Gerald Kanter - West Bloomfield MI, US Chitase Lee - Ann Arbor MI, US Joseph Repine - Ann Arbor MI, US Richard Skeean - Ann Arbor MI, US
International Classification:
A61K031/5415
US Classification:
514/226500
Abstract:
The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.