Charles M Radding

US Patent:

6391564, May 21, 2002

Filed:

Oct 27, 1998

Appl. No.:

09/179916

Inventors:

Thomas Haaf - Berlin, DE
Efim Ilya Golub - New Haven CT
Gurucharan Reddy - Redwood City CA
Charles Meyer Radding - Hamden CT
David C. Ward - Madison CT

Assignee:

Yale University - New Haven CT

International Classification:

G01N 3353

US Classification:

435 71, 436501, 5303871

Abstract:

Compositions and methods are provided for identifying and diagnosing individuals at risk for a disease state associated with aberrant Rad41 foci.

US Patent:

20030143533, Jul 31, 2003

Filed:

Oct 27, 1998

Appl. No.:

09/182102

Inventors:

THOMAS HAAF - BERLIN, DE
EFIM GOLUB - NEW HAVEN CT, US
GURUCHARAN REDDY - REDWOOD CITY CA, US
CHARLES MEYER RADDING - HAMDEN CT, US
DAVID C. WARD - MADISON CT, US

International Classification:

C12Q001/68
G01N033/48
C07H021/00

US Classification:

435/006000, 436/063000, 536/023100

Abstract:

In accordance with the objects outlined above, the present invention provides methods of diagnosing individuals at risk for a disease state which results in aberrant Rad51 loci. The methods comprise determining the distribution of Rad51 foci in a first tissue type of a first individual, and then comparing the distribution to the distribution of Rad51 foci from a second normal tissue type from the first individual or a second unaffected individual. A difference in the distributions indicates that the first individual is at risk for a disease state which results in aberrant Rad51 loci. Preferred disease states include cancer and disease states associated with apoptosis.

US Patent:

20030208053, Nov 6, 2003

Filed:

Oct 27, 1998

Appl. No.:

09/181027

Inventors:

THOMAS HAAF - BERLIN, DE
EFIM ILYA GOLUB - NEW HAVEN CT, US
GURUCHARAN REDDY - REDWOOD CITY CA, US
CHARLES MEYER RADDING - HAMDEN CT, US

International Classification:

C07H021/00
A01N037/18
A01N043/04
C12N005/00

US Classification:

536/023100, 435/325000, 514/002000, 514/044000

Abstract:

In accordance with the objects outlined above, the present invention provides methods of diagnosing individuals at risk for a disease state which results in aberrant Rad51 loci. The methods comprise determining the distribution of Rad51 foci in a first tissue type of a first individual, and then comparing the distribution to the distribution of Rad51 foci from a second normal tissue type from the first individual or a second unaffected individual. A difference in the distributions indicates that the first individual is at risk for a disease state which results in aberrant Rad51 loci. Preferred disease states include cancer and disease states associated with apoptosis. In an additional aspect, the present invention provides methods for identifying apoptotic cells and cells under stress associated with nucleic acid modification. The methods comprise determining the distribution of Rad51 foci in a first cell, and comparing the distribution to the distribution of Rad51 foci from a second non-apoptotic cell. A difference in the distributions indicates that the first cell is apoptotic or under stress.

US Patent:

20050118614, Jun 2, 2005

Filed:

Aug 4, 2004

Appl. No.:

10/912594

Inventors:

Gurucharan Reddy - Redwood City CA, US
Efim Golub - New Haven CT, US
Charles Radding - Hamden CT, US

International Classification:

A61K048/00
C12Q001/68
C12N009/12
C12P019/34

US Classification:

435006000, 514044000, 435091200

Abstract:

The invention relates to complexes of eukaryotic Rad52 protein and nucleic acids, and methods of using the complexes.

US Patent:

48882747, Dec 19, 1989

Filed:

Jan 20, 1987

Appl. No.:

7/005470

Inventors:

Charles M. Radding - Hamden CT
Saul M. Honigberg - New Haven CT
Sherman Weissman - New Haven CT
Basil Rigas - New York NY
Andrew A. Welcher - New Haven CT
David C. Ward - Guilford CT

Assignee:

Yale University - New Haven CT

International Classification:

C12Q 168
C07H 2100
C12N 1500

US Classification:

435 6

Abstract:

A stable, single-stranded nucleoprotein filament adapted to complex specifically and stably with a target duplex DNA having a selected base sequence. The filament is composed of a single-stranded DNA probe having a region of homology with the target base sequence, and RecA protein bound stably to the DNA probe by adenosine 5'-(. gamma. -thio)triphosphate. The filament is useful in a novel system and method for enriching target duplex DNA which contains a region homologous to the probe sequence, for blocking selected restriction endonuclease sites in the target DNA, and in other DNA methodologies in which stable rapid triple-strand synaptic formation in duplex DNA can be exploited.

US Patent:

59898798, Nov 23, 1999

Filed:

Jan 10, 1997

Appl. No.:

8/781329

Inventors:

Gurucharan Reddy - Redwood City CA
Efim Ilya Golub - New Haven CT
Charles Meyer Radding - Hamden CT

Assignee:

Yale University - New Haven CT

International Classification:

C12N 1563
C12N 2106
C07K 1300
C07H 2104

US Classification:

4351723

Abstract:

The invention relates to complexes of eukaryotic Rad52 protein and nucleic acids, and methods of using the complexes.

US Patent:

60905395, Jul 18, 2000

Filed:

Jan 14, 1998

Appl. No.:

9/007020

Inventors:

Thomas Haaf - Berlin, DE
Efim Ilya Golub - New Haven CT
Gurucharan Reddy - Redwood City CA
Charles Meyer Radding - Hamden CT
David C. Ward - Madison CT

Assignee:

Yale University - New Haven CT

International Classification:

C12Q 100

US Classification:

435 4

Abstract:

Compositions and methods are provided for identifying agents which bind to or modulate Rad51.

Author:

Charles M. Radding

ISBN #:

0300049188

Author:

Charles M. Radding

ISBN #:

0300061307

Author:

Charles M. Radding

ISBN #:

0300060890

Author:

Charles M. Radding

ISBN #:

0807816647

Author:

Charles Radding

ISBN #:

0231126840

Author:

Charles Radding

ISBN #:

0231126859

Author:

Charles Radding

ISBN #:

0300039093

Author:

Charles Radding

ISBN #:

0531022668