Charles C Pak

US Patent:

6339069, Jan 15, 2002

Filed:

Jun 29, 1999

Appl. No.:

09/343650

Inventors:

Paul R. Meers - Princeton NJ
Charles Pak - Princeton NJ
Shaukat Ali - Monmouth Junction NJ
Andrew Janoff - Yardley PA
J. Craig Franklin - Skillman NJ
Ravi K. Erukulla - Plainsboro NJ
Donna Cabral-Lilly - Princeton NJ
Patrick L. Ahl - Princeton NJ

Assignee:

Elan PharmaceuticalsTechnologies, Inc. - King of Prussia PA

International Classification:

A61K 4800

US Classification:

514 44, 424450, 4353201, 435455, 435458

Abstract:

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e. g. , tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.

US Patent:

61437166, Nov 7, 2000

Filed:

Oct 7, 1998

Appl. No.:

9/168010

Inventors:

Paul R. Meers - Princeton Junction NJ
Charles Pak - Plainsboro NJ
Shaukat Ali - Monmouth Junction NJ
Andrew Janoff - Yardley PA
J. Craig Franklin - East Windsor NJ
Ravi K. Erukulla - Plainsboro NJ
Donna Cabral-Lilly - Lawrenceville NJ

Assignee:

The Liposome Company, Inc. - Princeton NJ

International Classification:

A61K 3800
A61K 9127
C07K 500
C07K 700

US Classification:

514 2

Abstract:

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e. g. , tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.

US Patent:

60873256, Jul 11, 2000

Filed:

Oct 15, 1997

Appl. No.:

8/950618

Inventors:

Paul R. Meers - Princeton Junction NJ
Charles Pak - Plainsboro NJ
Shaukat Ali - Monmouth Junction NJ
Andrew Janoff - Yardley PA
J. Craig Franklin - East Windsor NJ
Ravi K. Erukulla - Plainsboro NJ
Donna Cabral-Lilly - Lawrenceville NJ

Assignee:

The Liposome Company, Inc. - Princeton NJ

International Classification:

A61K 3800
A61K 9127
C07K 500
C07K 700

US Classification:

514 2

Abstract:

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e. g. , tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.

US Patent:

62941917, Sep 25, 2001

Filed:

Jan 19, 2000

Appl. No.:

9/487053

Inventors:

Paul R. Meers - Princeton Junction NJ
Tong Shangguan - Princeton NJ
Shaukat Ali - Monmouth Junction NJ
Andrew Janoff - Yardley PA
Charles Pak - Plainsboro NJ

Assignee:

The Liposome Company, Inc. - Princeton NJ

International Classification:

A61K 9127

US Classification:

424450

Abstract:

This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.

US Patent:

61207977, Sep 19, 2000

Filed:

Oct 15, 1997

Appl. No.:

8/951056

Inventors:

Paul R. Meers - Princeton Junction NJ
Tong Shangguan - Princeton NJ
Shaukat Ali - Monmouth Junction NJ
Andrew Janoff - Yardley PA
Charles Pak - Plainsboro NJ

Assignee:

The Liposome Company, Inc. - Princeton NJ

International Classification:

A61K 9127

US Classification:

424450

Abstract:

This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.

Author:

Charles Y. Pak

ISBN #:

0898388864