Chang L Huang

US Patent:

6759039, Jul 6, 2004

Filed:

Jun 29, 2001

Appl. No.:

09/895585

Inventors:

Tianli Zheng - Culver City CA
Chang Jiang Huang - Los Angeles CA

Assignee:

AmCyte, Inc. - Santa Monica CA

International Classification:

A61K 3539

US Classification:

424 937, 435347, 435373, 435375, 435402

Abstract:

This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be propagated in a stable manner in successive serial passaging while maintaining insulin production in response to glucose. These cells are advantageous in that they are both expandable and stable in culture and can driven to late stage development, i. e. prototype islet cells. This invention further provides for culturing techniques that select for these intermediate differentiated stage cells and selectively eliminates early or late stage pancreatic cells.

US Patent:

8278956, Oct 2, 2012

Filed:

Apr 8, 2010

Appl. No.:

12/756578

Inventors:

Matt Losey - Rancho Cucamonga CA, US
Melvin Khoo - San Gabriel CA, US
Yohannes Desta - Arcadia CA, US
Chang Huang - Arcadia CA, US

Assignee:

Advantest America, Inc - San Jose CA

International Classification:

G01R 31/00

US Classification:

32475603, 32475407, 32475403, 32475701, 32475702

Abstract:

A microelectronic contactor assembly can include a probe head having microelectronic contactors for contacting terminals of semiconductor devices to test the semiconductor devices. A stiffener assembly can provide mechanical support to microelectronic contactors and for connecting a probe card assembly to a prober machine. A stiffener assembly may include first and second stiffener bodies that are connected together at their central portions with adjustment mechanisms such as three differential screw mechanisms. A probe head may be attached to a first stiffener body at locations outside its central portion, while a prober machine may be attached to a second stiffener body at locations outside its central portion. The first and second stiffener bodies may have different coefficients of thermal expansion. The stiffener assembly allows for differential thermal expansion of various components of the microelectronic contactor assembly while minimizing accompanying dimensional distortion that could interfere with contacting the terminals of semiconductor devices.

US Patent:

20040141957, Jul 22, 2004

Filed:

Feb 10, 2004

Appl. No.:

10/776099

Inventors:

Tianli Zheng - Culver City CA, US
Chang Huang - Los Angeles CA, US

Assignee:

AmCyte, Inc. - Santa Monica CA

International Classification:

A61K045/00
C12N005/08

US Classification:

424/093700, 435/366000

Abstract:

This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be propagated in a stable manner in successive serial passaging while maintaining insulin production in response to glucose. These cells are advantageous in that they are both expandable and stable in culture and can driven to late stage development, i.e. prototype islet cells. This invention further provides for culturing techniques that select for these intermediate differentiated stage cells and selectively eliminates early or late stage pancreatic cells.