Cecilia S Georgescu

US Patent:

7255895, Aug 14, 2007

Filed:

Jan 21, 2003

Appl. No.:

10/348165

Inventors:

Sukanta Banerjee - North Brunswick NJ, US
Cecilia Georgescu - Piscataway NJ, US
Michael Seul - Fanwood NJ, US

Assignee:

BioArray Solutions, Ltd. - Warren NJ

International Classification:

B05D 7/00

US Classification:

427212, 427222, 106 3113, 106 3127

Abstract:

Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.

US Patent:

7498054, Mar 3, 2009

Filed:

Jul 12, 2005

Appl. No.:

11/179135

Inventors:

Sukanta Banerjee - North Brunswick NJ, US
Cecilia Georgescu - Piscataway NJ, US
Michael Seul - Fanwood NJ, US

Assignee:

BioArray Solutions, Ltd. - Warren NJ

International Classification:

B05D 7/00
C09D 11/00

US Classification:

427212, 427222, 106 3113, 106 3127

Abstract:

Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.

US Patent:

20040139565, Jul 22, 2004

Filed:

Jan 21, 2003

Appl. No.:

10/348123

Inventors:

Sukanta Banerjee - North Brunswick NJ, US
Cecilia Georgescu - Piscataway NJ, US
Eric Daniels - Bethlehem PA, US
Victoria Dimonie - Bethlehem PA, US
Michael Seul - Fanwood NJ, US

International Classification:

D06P003/52

US Classification:

008/509000

Abstract:

A dye, such as a fluorescent dye, is incorporated into polymer microparticles using a solvent system composed of a first solvent in which the dye and the microparticle polymer are soluble, a second solvent in which the dye and the microparticle polymer are not or only weakly soluble, and a third solvent in which the dye and the microparticle polymer are not or only weakly soluble. The first and second solvents are immiscible with each other, or at most partially miscible. The third solvent is miscible with the first and second solvents. The formulation provides substantially complete partitioning of the dye to the microparticles. The method may be used to obtain dyed polymer microparticle formed of cross-linked or non-cross-linked polymers. Libraries are provided comprising two or more sets of microparticles of different dye loadings. Fluorescent core-shell microparticles are produced from a mixture of microparticle cores incorporating one or more fluorescent dyes, a polymerization mixture comprising at least one polymerizable shell monomer, at least one free radical polymerization initiator comprising a water-insoluble oxidizing agent, and at least one water-soluble reducing agent.

US Patent:

20080282483, Nov 20, 2008

Filed:

Mar 14, 2007

Appl. No.:

11/685875

Inventors:

Sukanta Banerjee - North Brunswick NJ, US
Cecilia Georgescu - Piscataway NJ, US
Michael Seul - Fanwood NJ, US

International Classification:

D06P 3/79
D06P 3/04
D06P 3/00

US Classification:

8514, 8506, 8513

Abstract:

Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.

US Patent:

20120220715, Aug 30, 2012

Filed:

Mar 12, 2012

Appl. No.:

13/417791

Inventors:

Sukanta Banerjee - North Brunswick NJ, US
Cecilia Georgescu - Piscataway NJ, US
Michael Seul - Fanwood NJ, US

International Classification:

C08L 25/08

US Classification:

524556

Abstract:

Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.