Cathy A Swindlehurst

US Patent:

20130116317, May 9, 2013

Filed:

Jun 7, 2011

Appl. No.:

13/702041

Inventors:

Leah M. Fung - San Diego CA, US
Kyle W.H. Chan - San Diego CA, US
Cathy A. Swindlehurst - San Diego CA, US

Assignee:

NOVOMEDIX, LLC - San Diego CA

International Classification:

A61K 31/341
A61K 45/06
C07D 307/68

US Classification:

514471, 549487

Abstract:

Provided herein are substituted furanyl compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

US Patent:

20200062700, Feb 27, 2020

Filed:

Nov 5, 2019

Appl. No.:

16/674943

Inventors:

- San Diego CA, US
Kyle W. H. Chan - San Diego CA, US
Cathy A. Swindlehurst - San Diego CA, US
Robert W. Sullivan - Vista CA, US

International Classification:

C07C 311/21
A61K 31/18
A61K 31/337
A61K 45/06

Abstract:

Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

US Patent:

20180327353, Nov 15, 2018

Filed:

Jul 26, 2018

Appl. No.:

16/046893

Inventors:

- San Diego CA, US
Kyle W.H. Chan - San Diego CA, US
Cathy A. Swindlehurst - San Diego CA, US
Robert W. Sullivan - Vista CA, US

International Classification:

C07C 311/21
A61K 45/06
A61K 31/18
A61K 31/337

Abstract:

Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

US Patent:

20180127359, May 10, 2018

Filed:

Nov 8, 2017

Appl. No.:

15/806952

Inventors:

- San Diego CA, US
Kyle W.H. Chan - San Diego CA, US
Robert W. Sullivan - Vista CA, US
Cathy A. Swindlehurst - San Diego CA, US

International Classification:

C07C 279/04
A61K 9/28
A61K 31/155
A61K 45/06
A61P 9/12
A61P 9/00
A61P 3/10

Abstract:

Provided herein are nitrite salts of 1,1-dimethylbiguanide; and isotopic variants thereof; and pharmaceutically acceptable hydrates and solvates thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of diseases associated with and/or caused by an abnormal blood glucose level. Further provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a cardiovascular disease.

US Patent:

20170158627, Jun 8, 2017

Filed:

Feb 16, 2017

Appl. No.:

15/434531

Inventors:

- San Diego CA, US
Kyle W.H. Chan - San Diego CA, US
Cathy A. Swindlehurst - San Diego CA, US
Robert W. Sullivan - Vista CA, US

International Classification:

C07C 311/21
A61K 45/06
A61K 31/18

Abstract:

Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

US Patent:

20160024040, Jan 28, 2016

Filed:

Sep 30, 2015

Appl. No.:

14/871552

Inventors:

- San Diego CA, US
Kyle W.H. Chan - San Diego CA, US
Cathy A. Swindlehurst - San Diego CA, US

International Classification:

C07D 307/68
A61K 31/341

Abstract:

Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

US Patent:

20160016899, Jan 21, 2016

Filed:

Sep 30, 2015

Appl. No.:

14/871472

Inventors:

- San Diego CA, US
Kyle W.H. Chan - San Diego CA, US
Cathy A. Swindlehurst - San Diego CA, US
Robert W. Sullivan - Vista CA, US

International Classification:

C07C 311/21
A61K 31/337
A61K 31/18

Abstract:

Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

US Patent:

20140309297, Oct 16, 2014

Filed:

Apr 10, 2014

Appl. No.:

14/250089

Inventors:

- San Diego CA, US
Kyle W.H. CHAN - San Diego CA, US
Cathy A. SWINDLEHURST - San Diego CA, US

Assignee:

NovoMedix, LLC - San Diego CA

International Classification:

C07D 307/68

US Classification:

514471, 549487

Abstract:

Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.