Carroll A Ball

US Patent:

7829032, Nov 9, 2010

Filed:

Jan 23, 2008

Appl. No.:

12/011220

Inventors:

Robert Michael Van Dam - Glendale CA, US
Carroll Edward Ball - San Diego CA, US
Arkadij M. Elizarov - Valley Village CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

B01J 19/00

US Classification:

422159

Abstract:

The present application relates to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and a method of using such instruments.

US Patent:

8071035, Dec 6, 2011

Filed:

Apr 14, 2008

Appl. No.:

12/102822

Inventors:

Arkadij M Elizarov - Valley Village CA, US
Carroll Edward Ball - Del Mar CA, US
Jianzhong Zhang - Brea CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
R. Michael Van Dam - Glendale CA, US
Lawrence Talcott Diener - Long Beach CA, US
Sean Ford - Lake Zurich IL, US
Reza Miraghaie - Culver City CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

G21C 1/00
B01J 19/00
B01J 10/00
B01L 3/00
B01L 3/02
F16K 3/00

US Classification:

422159, 422129, 422130, 422500, 422501, 422502, 422504, 422505, 422507, 422509, 422521, 422522, 422523, 422524, 422537, 422547, 422600, 422603

Abstract:

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

US Patent:

8110148, Feb 7, 2012

Filed:

Nov 4, 2009

Appl. No.:

12/612091

Inventors:

Carroll Edward Ball - Los Angeles CA, US
Arkadij M. Elizarov - Woodland Hills CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
Reza Miraghaie - Culver City CA, US
Jianzhong Zhang - Brea CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

B01J 19/00
B01J 10/00
B01J 12/00
B01J 14/00

US Classification:

422130, 422129, 422131, 422159

Abstract:

Methods and apparatus for facilitating the synthesis of compounds in a batch device are presented. Application of the batch type microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the selective introduction of multiple reagents via an enhanced rotary flow distribution valve through a single inlet port of the synthetic device. The sequential introduction of multiple reagents through a single inlet port allows an optimal delivery of highly concentrated reagents into the reactor and facilitates the synthesis of the desired products with a minimal loss of materials during transfers, which is critical to the synthesis of radiolabeled biomarkers.

US Patent:

8173073, May 8, 2012

Filed:

Oct 29, 2010

Appl. No.:

12/915149

Inventors:

Arkadij M. Elizarov - Woodland Hills CA, US
Carroll Edward Ball - Los Angeles CA, US
Jianzhong Zhang - Brea CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
R. Michael Van Dam - Los Angeles CA, US
Lawrence Diener - Long Beach CA, US
Sean Ford - Oceanside CA, US
Reza Miraghaie - Culver City CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

G21C 1/00
B01J 19/00
B01J 8/00
G01N 23/00
G01N 30/02

US Classification:

422159, 422129, 422130, 422600, 422603, 436 57, 436161

Abstract:

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

US Patent:

8214159, Jul 3, 2012

Filed:

Dec 3, 2009

Appl. No.:

12/630298

Inventors:

Jianzhong Zhang - Brea CA, US
Arkadij M. Elizarov - Woodland Hills CA, US
Reza Miraghaie - Culver City CA, US
Carroll Edward Ball - Los Angeles CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

G01N 31/00

US Classification:

702 31

Abstract:

Methods and apparatus to assess current aspects of Quality Control useful for release of radioactive compounds for imaging, such as PET tracers as injectables, in an automated manner, without user interference, and in compliance with regulatory guidelines. The present method and system relates to an integrated automated quality control analysis of a substance utilizing a single sample injection for a plurality of inline quality control tests. A quantitative analysis of the sample via the plurality of quality control tests is conducted. A measurement value of each of the plurality of quality control parameters is determined and a comparison of each measurement value of the plurality of quality control parameters with a predetermined corresponding criterion value is made. A cumulative quality rating for the sample is determined and the validated sample is released based on the quality rating.

US Patent:

8273300, Sep 25, 2012

Filed:

Jul 8, 2010

Appl. No.:

12/803862

Inventors:

Arkadij M. Elizarov - Woodland Hills CA, US
Carroll Edward Ball - Los Angeles CA, US
Jianzhong Zhang - Brea CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
Reza Miraghaie - Culver City CA, US
Todd Graves - Knoxville TN, US
Artem Lebedev - Culver City CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

G21C 1/00
B01J 19/00
B01J 8/00

US Classification:

422159, 422129, 422130, 422600, 422603

Abstract:

Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

US Patent:

8435454, May 7, 2013

Filed:

Jan 7, 2011

Appl. No.:

12/986323

Inventors:

Arkadij M. Elizarov - Woodland Hills CA, US
Carroll Edward Ball - Los Angeles CA, US
Jianzhong Zhang - Brea CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
Reza Miraghaie - Culver City CA, US
Todd L. Graves - Knoxville TN, US
Artem Lebedev - Culver City CA, US
Keith E. Schleiffer - Knoxville TN, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

G21C 1/00
B01J 19/00

US Classification:

422159, 422903, 422130

Abstract:

Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

US Patent:

20100093098, Apr 15, 2010

Filed:

Oct 13, 2009

Appl. No.:

12/578175

Inventors:

Carroll Edward Ball - Los Angeles CA, US
Arkadij Elizarov - Woodland Hills CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US

Assignee:

Siemens Medical Solutions - Malvern PA

International Classification:

G01N 1/40
B01D 1/00
B01D 1/16
G01N 35/08
G05D 7/00
G05D 16/00
G05D 23/00
G05D 27/00

US Classification:

436 50, 422231, 422159, 422198, 422202, 422119, 422111, 423249

Abstract:

Methods and apparatus for facilitating the synthesis of compounds in a nonflow-through device are presented. Application of the nonflow-through methods and microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the introduction of a pressurized gas through a tangential slit into a vortex reactor of the nonflow-through device, while one or more liquids are delivered to the reaction chamber through the same or different inlet ports. The introduction of the pressurized gas produces a cyclonic motion of the mixture within the reactor. Such a mechanism may be used to facilitate the evaporation of various liquids within the reactor at lower temperatures, thus reducing the production of unwanted byproducts that are associated with the use of high temperatures. In addition, thorough mixing of various liquids may be effected rapidly while allowing chemical reactions to take place efficiently within the vortex reactor.