C. Wayne Bardin - New York NY Carl Monder - Teaneck NJ
The Population Council, Inc. - New York NY
A particular group of androgens is not metabolized to their 5. alpha. -reduced form in the prostate and other tissues. Thus, administration of these compounds--testosterone derivatives with a non-hydrogen substituent in the 6. alpha. or 7. alpha. position--allows one to provide androgen supplementation therapy without stimulating abnormal prostate growth. A preferred compound for use in the invention is 7. alpha. -methyl-19-nortestosterone.