Carl I Hansen

Author:

Carl E. Hansen

ISBN #:

0205070949

Author:

Carl L. Hansen

ISBN #:

0299512371

Author:

Carl J. Hansen

ISBN #:

9027704066

Author:

Carl J. Hansen

ISBN #:

9027704074

Author:

Carl Johan Hansen

ISBN #:

8774915649

Author:

Carl F. Hansen

ISBN #:

0837197074

US Patent:

6899137, May 31, 2005

Filed:

Apr 6, 2001

Appl. No.:

09/826583

Inventors:

Marc A. Unger - South San Francisco CA, US
Todd A. Thorsen - Pasadena CA, US
Axel Scherer - Laguna Beach CA, US
Stephen R. Quake - San Marino CA, US
Markus M. Enzelberger - Pasadena CA, US
Mark L. Adams - Pasadena CA, US
Carl L. Hansen - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

F15C001/06

US Classification:

137833, 137803, 137807, 137824, 13756516

Abstract:

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

US Patent:

6929030, Aug 16, 2005

Filed:

Nov 28, 2001

Appl. No.:

09/997205

Inventors:

Marc A. Unger - South San Francisco CA, US
Todd A. Thorsen - Pasadena CA, US
Axel Scherer - Laguna Beach CA, US
Stephen R. Quake - San Marino CA, US
Jian Liu - Pasadena CA, US
Mark L. Adams - Pasadena CA, US
Carl L. Hansen - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

F16K031/126

US Classification:

137883, 251 611

Abstract:

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

US Patent:

7216671, May 15, 2007

Filed:

Feb 10, 2005

Appl. No.:

11/056451

Inventors:

Marc Unger - South San Francisco CA, US
Todd Thorsen - Pasadena CA, US
Axel Scherer - Laguna Beach CA, US
Stephen Quake - San Marino CA, US
Markus Enzelberger - Pasadena CA, US
Mark Adams - Pasadena CA, US
Carl Hansen - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

F15C 1/06

US Classification:

137833, 137803, 137807, 137824, 13756516

Abstract:

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

US Patent:

7250128, Jul 31, 2007

Filed:

Apr 20, 2005

Appl. No.:

11/111264

Inventors:

Marc A. Unger - South San Francisco CA, US
Todd A. Thorsen - Pasadena CA, US
Axel Scherer - Laguna Beach CA, US
Stephen R. Quake - San Marino CA, US
Jian Liu - Pasadena CA, US
Mark L. Adams - Pasadena CA, US
Carl L. Hansen - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

B29C 39/02

US Classification:

264155, 264238, 264250, 264310, 264319

Abstract:

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

US Patent:

7326296, Feb 5, 2008

Filed:

May 23, 2005

Appl. No.:

11/135923

Inventors:

Stephen R. Quake - Stanford CA, US
Carl L. Hansen - Pasadena CA, US
James M. Berger - Kensington CA, US

Assignee:

California Institute of Technology - Pasadena CA
The Regents of the University of California - Oakland CA

International Classification:

C30B 29/00

US Classification:

117200, 117 68, 117 69, 4222451

Abstract:

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

US Patent:

7754010, Jul 13, 2010

Filed:

Oct 31, 2007

Appl. No.:

11/932171

Inventors:

Marc A. Unger - South San Francisco CA, US
Todd A. Thorsen - Pasadena CA, US
Axel Scherer - Laguna Beach CA, US
Stephen R. Quake - San Marino CA, US
Markus M. Enzelberger - Pasadena CA, US
Mark L. Adams - Pasadena CA, US
Carl L. Hansen - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C30B 29/54

US Classification:

117 68, 117 69, 117 70, 117925

Abstract:

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

US Patent:

7766055, Aug 3, 2010

Filed:

Oct 31, 2007

Appl. No.:

11/932107

Inventors:

Marc A. Unger - South San Francisco CA, US
Todd A. Thorsen - Pasadena CA, US
Axel Scherer - Laguna Beach CA, US
Stephen R. Quake - San Marino CA, US
Markus M. Enzelberger - Pasadena CA, US
Mark L. Adams - Pasadena CA, US
Carl L. Hansen - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

B65B 31/00

US Classification:

141 5, 141 4, 141 39

Abstract:

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

US Patent:

8104497, Jan 31, 2012

Filed:

Mar 13, 2007

Appl. No.:

11/685654

Inventors:

Marc Unger - South San Francisco CA, US
Todd Thorsen - Pasadena CA, US
Axel Scherer - Laguna Beach CA, US
Stephen Quake - San Marino CA, US
Markus Enzelberger - Pasadena CA, US
Mark Adams - Pasadena CA, US
Carl Hansen - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

B08B 3/04

US Classification:

137 1505, 137197, 137833

Abstract:

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.