Carl D Grove

US Patent:

6355270, Mar 12, 2002

Filed:

Jan 6, 2000

Appl. No.:

09/479389

Inventors:

Mauro Ferrari - Dublin OH
Peter J. Dehlinger - Palo Alto CA
Francis J. Martin - San Francisco CA
Carl F. Grove - Portola Valley CA
David R. Friend - Menlo Park CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 914

US Classification:

424489, 424450, 424451, 4241851, 514 2, 514 21, 530300, 530350

Abstract:

Microfabricated, asymmetrical, reservoir-containing particles for use in the oral delivery of biopolymer therapeutic agents such as peptides, proteins and oligonucleotides are disclosed. The particles are encapsulated in enteric-coated capsules or tablets to provide passage through the stomach and release of a suspension of the particles in the intestinal lumen. The particles have a selected shape, and uniform dimensions preferably in the 100 m to 1 mm range. The reservoirs open to the face of the particle and are filled with a therapeutic agent and selected excipients. The excipients are selected to delay the dissolution/release of the agent from the particle reservoirs for 5-60 minutes after the particle is released in the intestinal lumen. Alternatively, the pore is plugged with an erodable material. The face of the particle is grafted with a layer of muco-adhesive ligands designed to quickly bind the particle to the intestinal mucosa for several minutes to several hours after release of the particles from the enteric-coated carrier.

US Patent:

20020128179, Sep 12, 2002

Filed:

Nov 30, 2001

Appl. No.:

10/020464

Inventors:

William Tacon - Westerville OH, US
Anthony Boiarski - Hilliard OH, US
Carl Grove - Upper Arlington OH, US
Richard Brody - Worthington OH, US

International Classification:

A61K048/00
A61L009/04
A61K009/14
A61K039/395

US Classification:

514/002000, 424/046000, 514/044000, 424/130100

Abstract:

Microparticles for use in the pulmonary delivery of a therapeutic material, comprising a polymer matrix, which is prefabricated to have a particular geometric shape including that of a disc cube, rectangle or snowflake. Additionally, these microparticles may include a winged structure to enhance the aerodynamic characteristics of said microparticle. Microfabrication methods for making these microparticles are provided.