Camille N Abboud

US Patent:

20070031406, Feb 8, 2007

Filed:

Oct 22, 2004

Appl. No.:

10/576428

Inventors:

Martin Zand - Rochester NY, US
Jainulabdeen Ifthikharuddin - Rochester NY, US
Jane Liesveld - Rochester NY, US
Camille Abboud - Rochester NY, US

International Classification:

A61K 39/395

US Classification:

424144100, 424155100

Abstract:

Methods and products are described for inducing B cell apoptosis, using antibody-induced apoptosis. Specifically, polyclonal antiserum or one or more monoclonal antibodies, either alone or in combination, as well as fragments or variants thereof are employed in the methods and products of the present invention. These antibodies, or fragments or variants thereof, are capable of binding to B cell surface markers under conditions effective to collectively or individually induce apoptosis of the contacted B cell. Consequently, the methods and products of the present invention can be used therapeutically to treat, or as a preventative agent to protect against, a B cell-related condition or disorder.

US Patent:

20030171551, Sep 11, 2003

Filed:

Jan 30, 1998

Appl. No.:

09/016743

Inventors:

JOSEPH D. ROSENBLATT - ROCHESTER NY, US
PIA CHALLITA-EID - ROCHESTER NY, US
SHERIE MORRISON - LOS ANGELES CA, US
CAMILLE N. ABBOUD - ROCHESTER NY, US
SEUNG-UON SHIN - LOS ANGELES CA, US

International Classification:

A61K039/395
A61K039/40
A61K039/42
C07K001/00
C07K014/00
C07K017/00
C12P021/08
C07K016/00

US Classification:

530/388800, 530/350000, 530/387300, 530/387700, 424/133100, 424/134100, 424/138100

Abstract:

The present invention relates to chimeric molecules for the stimulation of an anti-tumor immune response to facilitate immune eradication of breast, ovarian and other cancer cells. The chimeric molecules include a binding region which specifically binds to a tumor specific antigen and a chemokine and/or costimulatory ligand. The invention further provides methods for inducing a tumor specific immune response and compositions which can be administered to mammals.