Brian R Hamilton

US Patent:

20070298099, Dec 27, 2007

Filed:

Nov 18, 2005

Appl. No.:

11/667344

Inventors:

Andrey Peresypkin - Cranford NJ, US
Eleni Dokou - Harleysville PA, US
Craig McKelvey - Ambler PA, US
Charles DeLuca - Royersford PA, US
Laman Alani - Lansdale PA, US
Todd Gibson - North Haven CT, US
Danielle Euler - Souderton PA, US
Santipharp Panmai - West Point PA, US
W. Wuelfing - Schwenksville PA, US
Thomas Gandek - Collegeville PA, US
Drazen Ostovic - Newbury Park CA, US
Timothy Rhodes - South Orange NJ, US
Brian Hamilton - Lansdale PA, US

International Classification:

A61K 9/48
A61K 31/44
A61P 25/30
A61P 3/04
A61P 3/10

US Classification:

424456000, 514351000

Abstract:

N-[1S,2S]-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-trifluoromethyl]pyridine-2-yl}oxy}propanamide (Compound I) has surprisingly improved solubility and bioavailability in a lipophilic vehicle comprising a pharmaceutically acceptable digestible oil, a surfactant, or a cosolvent, or a mixture of any two or more thereof. In one embodiment of the present invention are self-emulsifying or self-microemulsifying composition comprising 1) Compound I; 2) a surfactant having an HLB of 1 to 8; and 3) a surfactant having an HLB of over 8 to 20; and optionally, 4) a digestible oil and/or cosolvent and/or antioxidant or preservative.