Bruce N Cronstein

Author:

Bruce N. Cronstein

ISBN #:

0849339995

US Patent:

6555545, Apr 29, 2003

Filed:

Feb 12, 2001

Appl. No.:

09/780365

Inventors:

Bruce N. Cronstein - New York NY
Edwin Chan - New York NY

Assignee:

New York University - New York NY

International Classification:

A61K 31519

US Classification:

514261, 514 46, 514258, 514262, 514263, 514266, 544242, 544239, 544253, 544256, 544262, 544264, 544265, 536 2613

Abstract:

Hepatic cirrhosis and fibrosis and fatty liver can be prevented and treated by administering to a subject in need thereof an effective amount of at least one adenosine A receptor antagonist or at least one adenosine uptake promotor.

US Patent:

7795427, Sep 14, 2010

Filed:

Feb 13, 2007

Appl. No.:

11/705689

Inventors:

Bruce N. Cronstein - New York NY, US
Firas Mohamed Kara - Woodside NY, US

Assignee:

New York University - New York NY

International Classification:

C07D 473/00

US Classification:

544267, 424 92

Abstract:

The invention provides methods and compositions for modulating osteoclastogenesis and for treating bone diseases characterized by bone loss or a decrease in bone mass or density, by administering a compound or agent that modulates the adenosine A1 receptor, in particular, an inhibitor or antagonist of the A1 receptor.

US Patent:

8183225, May 22, 2012

Filed:

Nov 10, 2008

Appl. No.:

12/291510

Inventors:

Bruce N. Cronstein - New York NY, US
Zhong Sheng Peng - New York NY, US

Assignee:

New York University - New York NY

International Classification:

A01N 43/04
C07H 19/16
A61K 31/52
C07K 14/705

US Classification:

514 46, 536 273

Abstract:

The invention provides methods and compositions for reducing or inhibiting bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that modulates an adenosine receptor such as the adenosine Areceptor, in particular, an agonist of an adenosine Areceptor. The invention also extends to pharmaceutical compositions comprising such an agent that modulates an adenosine receptor such as an adenosine Aagonist and to prosthetic devices containing such an agent that modulates an adenosine receptor such as an Aagonist on one or more surfaces or within the prosthetic device such as, for example, suspended in the cement forming the prosthetic device.

US Patent:

20090208550, Aug 20, 2009

Filed:

Oct 24, 2008

Appl. No.:

12/290021

Inventors:

Bruce N. Cronstein - New York NY, US
Zhong Sheng Peng - New York NY, US

International Classification:

A61K 9/00
A61K 31/522
A61K 38/16
A61K 38/02
A61K 31/7052
A61K 39/395
A61K 31/7076
A61P 1/16

US Classification:

424422, 51426334, 514 12, 514 2, 514 44 R, 4241721, 514 45

Abstract:

The invention provides methods and compositions for treating a hepatic disease, for reducing fat deposition in the liver and for inhibiting fibrosis of the liver by administering a compound or agent that modulates an adenosine receptor, in particular, an inhibitor or antagonist of an adenosine receptor, especially an Aor Aadenosine receptor antagonist.

US Patent:

20120283211, Nov 8, 2012

Filed:

May 18, 2012

Appl. No.:

13/475067

Inventors:

Bruce N. Cronstein - New York NY, US
Aranzazu Mediero Munoz - New York NY, US

International Classification:

A61K 31/7076
A61P 19/00

US Classification:

514 45

Abstract:

The invention provides methods and compositions for reducing or inhibiting bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that modulates an adenosine receptor such as the adenosine Areceptor, in particular, an agonist of an adenosine Areceptor. The invention also extends to pharmaceutical compositions comprising such an agent that modulates an adenosine receptor such as an adenosine Aagonist and to prosthetic devices containing such an agent that modulates an adenosine receptor such as an Aagonist on one or more surfaces or within the prosthetic device such as, for example, suspended in the cement forming the prosthetic device.

US Patent:

59325585, Aug 3, 1999

Filed:

Sep 13, 1996

Appl. No.:

8/712942

Inventors:

Bruce N. Cronstein - New York NY
Richard I. Levin - New York NY

Assignee:

New York University - New York NY

International Classification:

A61K 3170

US Classification:

514 46

Abstract:

Agonists of the adenosine A. sub. 2 receptor promote the migration of endothelial cells, fibroblasts and epithelial cells. Thus, methods and pharmaceutical compositions useful for treating wounds and promoting wound healing comprise agents which cause stimulation of the adenosine A. sub. 2 receptor, preferably receptor agonists and adenosine uptake blockers. Preferred agonists include 2-phenylaminoadenosine, 2-para-2-carboxyethylphenyl-amino-5'N-ethylcarboxamidoadenosine, 5'N-ethylcarbox-amidoadenosine, 5'N-cyclopropyladenosine, 5'N-methyl-carboxamidoadenosine and PD-125944. Preferred uptake blockers include dipyridamole, nitrobenzylthio-inosine, dilazep and R75231.

US Patent:

63130912, Nov 6, 2001

Filed:

May 20, 1998

Appl. No.:

9/000179

Inventors:

Hans-Georg Wisniewski - New York NY
Jan Vilcek - New York NY
Bruce Cronstein - New York NY

Assignee:

New York University - New York NY

International Classification:

A61K 3800
C07K 1400
C07H 2102
A01N 3718
C12P 2106

US Classification:

514 12

Abstract:

Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a protein molecule, termed TSG-6, in connective tissue cells. TSG-6, or pharmaceutical compositions containing TSG-6, can be used to treat inflammatory diseases and disorders and cancer-related pathologies. Inflammatory diseases and disorders, or cancer related pathologies, can also be treated by introducing human cells transfected with a DNA molecule containing a DNA segment encoding TSG-6 protein, into humans to express therapeutically effective amounts of TSG-6 in vivo or by introducing a vector carrying a DNA segment encoding TSG-6 protein directly into humans in vivo.

US Patent:

60203218, Feb 1, 2000

Filed:

Feb 3, 1999

Appl. No.:

9/243538

Inventors:

Bruce N. Cronstein - New York NY
Richard I. Levin - New York NY

Assignee:

New York University - New York NY

International Classification:

A61K 3170
C07H 19167

US Classification:

514 46

Abstract:

Agonists of the adenosine A. sub. 2 receptor promote the migration of endothelial cells, fibroblasts and epithelial cells. Thus, methods and pharmaceutical compositions useful for treating wounds and promoting wound healing comprise agents which cause stimulation of the adenosine A. sub. 2 receptor, preferably receptor agonists and adenosine uptake blockers. Preferred agonists include 2-phenylaminoadenosine, 2-para-2-carboxyethylphenyl-amino-5'N-ethylcarboxamidoadenosine, 5'N-ethylcarbox-amidoadenosine, 5'N-cyclo-propyladenosine, 5'N-methylcarboxamidoadenosine and PD-125944. Preferred uptake blockers include dipyridamole, nitrobenzylthio-inosine, dilazep and R75231.