Broc A Flores

US Patent:

8466281, Jun 18, 2013

Filed:

Oct 15, 2009

Appl. No.:

13/124884

Inventors:

Paul J. Coleman - Harleysville PA, US
Christopher D. Cox - Harelysville PA, US
Broc Flores - Boston MA, US
John D. Schreier - Philadelphia PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 265/30
A61K 31/535

US Classification:

544106, 5142375

Abstract:

The present invention is directed to 2,5-disubstituted morpholine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

US Patent:

20110263643, Oct 27, 2011

Filed:

Oct 15, 2009

Appl. No.:

13/125191

Inventors:

Christopher D. Cox - Harelysville PA, US
Broc Flores - Boston MA, US
John D. Schreier - Philadephia PA, US

International Classification:

A61K 31/4545
A61P 25/20
A61K 31/4709
C07D 401/14
A61K 31/4725

US Classification:

514309, 546194, 546141, 546153, 514318, 514312

Abstract:

The present invention is directed to 2,3-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.