Brian A Erickson

US Patent:

20100081124, Apr 1, 2010

Filed:

Sep 30, 2008

Appl. No.:

12/241119

Inventors:

Klara Abravaya - Kenilworth IL, US
Brian J. Erickson - Kenosha WI, US
Shihai X. Huang - Evanston IL, US
John A. Salituro - Union Grove WI, US
Ning Tang - Libertyville IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12Q 1/70
C07H 21/04
C12Q 1/68

US Classification:

435 5, 536 2433, 536 2432, 435 6

Abstract:

The present invention relates to primers, probes, primer sets, primer and probe sets, methods and kits for detecting human papillomaviruses, human beta globin sequences and human papillomaviruses and human beta globin sequences in a test sample.

US Patent:

20130323727, Dec 5, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/840142

Inventors:

Hong X. Su - Evanston IL, US
Brian J. Erickson - Kenosha WI, US

International Classification:

C12Q 1/68

US Classification:

435 611, 536 2433, 536 253

Abstract:

A method of designing a primer for detecting a single nucleotide polymorphism (SNP), a method of detecting an SNP, a method of distinguishing SNPs, primers, detectable oligonucleotides, and kits.

US Patent:

20230132372, Apr 27, 2023

Filed:

Jul 28, 2021

Appl. No.:

17/387888

Inventors:

- Cambridge MA, US
- Boston MA, US
Steven P. Gygi - Cambridge MA, US
Gregory H. Bird - Pelham NH, US
Loren D. Walensky - Newton MA, US
Martin Helmut Wuhr - Cambridge MA, US
Brian K. Erickson - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA
Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

G01N 33/58
C07D 207/46
C07C 237/22
C07K 1/13
C07K 5/02
G01N 33/68

Abstract:

In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.

US Patent:

20190310264, Oct 10, 2019

Filed:

Jun 1, 2017

Appl. No.:

16/306686

Inventors:

- Cambridge MA, US
Brian K. Erickson - Brookline MA, US
Christopher Michael Rose - Fremont CA, US
Steven P. Gygi - Foxborough MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G01N 33/68

Abstract:

Described herein is a kit of materials prepared for assays that involve determining relative abundance and/or absolute abundance of various targeted peptides. The kit may comprise trigger versions of target peptides with masses offset from the respective target peptides by predetermined and known amounts. The trigger peptides may be present in amounts that may be readily detected via a mass spectrometry analysis. When mixed with samples that are analyzed, detection of the trigger peptides indicates where in the mass-spectrometer output the target peptide may be found. The kit may include a predetermined amount of synthetic versions of one or more of the target peptides. A measured relative abundance of this synthetic peptide relative to that of the target peptides yields an absolute quantitative value of the target peptide. Also disclosed is a method of preparing a plurality of samples to be submitted for mass spectrometer analysis in parallel.

US Patent:

20190153537, May 23, 2019

Filed:

Sep 27, 2018

Appl. No.:

16/143904

Inventors:

- Des Plaines IL, US
Brian Erickson - Des Plaines IL, US
Amanda Goldston - Des Plaines IL, US

International Classification:

C12Q 1/6876
C12Q 1/686
C12Q 1/6806

Abstract:

The disclosure is directed to methods, kits, and compositions, for amplifying and detecting a human hepatitis B virus (HBV) in a sample, which comprises a variety of combinations of forward oligonucleotide primers, reverse oligonucleotide primers, and oligonucleotide probes.

US Patent:

20190032133, Jan 31, 2019

Filed:

Aug 20, 2018

Appl. No.:

16/105057

Inventors:

- Des Plaines IL, US
Hong X. Su - Evanston IL, US
Brian J. Erickson - Kenosha WI, US

Assignee:

Abbott Molecular, Inc. - Des Plaines IL

International Classification:

C12Q 1/6876
C12Q 1/6858
C12Q 1/6886

Abstract:

A method of designing a primer for detecting a single nucleotide polymorphism (SNP), a method of detecting an SNP, a method of distinguishing SNPs, primers, detectable oligonucleotides, and kits.

US Patent:

20160053334, Feb 25, 2016

Filed:

Jul 9, 2015

Appl. No.:

14/795155

Inventors:

- Des Plaines IL, US
Chad Dunn - Chicago IL, US
John Salituro - Union Grove WI, US
Brian Erickson - Kenosha WI, US

International Classification:

C12Q 1/70
C12Q 1/68

Abstract:

The present invention provides novel and non-obvious improvements to dried blood spot testing for HIV-1 viral load useful for diagnosis and monitoring treatment progression.