Brett Weylan Ching

US Patent:

8148544, Apr 3, 2012

Filed:

Mar 18, 2011

Appl. No.:

13/051052

Inventors:

Xiaodong Li - San Diego CA, US
Andrew Patron - San Marcos CA, US
Catherine Tachdjian - San Diego CA, US
Hong Xu - San Diego CA, US
Qing Li - San Diego CA, US
Alexey Pronin - San Diego CA, US
Guy Servant - San Diego CA, US
Lan Zhang - San Diego CA, US
Thomas Brady - San Diego CA, US
Vincent Darmohusodo - San Diego CA, US
Melissa Arellano - San Diego CA, US
Victor Selchau - San Diego CA, US
Brett Weylan Ching - San Diego CA, US
Donald S. Karanewsky - Escondido CA, US
Paul Brust - San Diego CA, US
Jing Ling - Carlsbad CA, US
Wen Zhao - San Diego CA, US
Chad Priest - Encinitas CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

C07D 261/06

US Classification:

548247

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e. g. , coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e. g. , coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

US Patent:

20030039661, Feb 27, 2003

Filed:

Mar 1, 2002

Appl. No.:

10/087607

Inventors:

Teresa Aja - Imperial Beach CA, US
Brett Ching - San Diego CA, US
Patricia Gladstone - San Diego CA, US

International Classification:

A61K039/12
A61K039/21
A61K039/29

US Classification:

424/186100, 424/188100, 424/189100

Abstract:

The present invention relates generally to programmed cell death and specifically to methods, compositions, and kits for preserving or enhancing antigenicity of markers associated with disease by utilizing inhibitors of apoptosis including interleukin-1-converting enzyme (ICE)/CED-3 family inhibitors.

US Patent:

20090274632, Nov 5, 2009

Filed:

Aug 19, 2008

Appl. No.:

12/222918

Inventors:

Xiaodong Li - San Diego CA, US
Andrew Patron - San Marcos CA, US
Catherine Tachdjian - San Diego CA, US
Hong Xu - San Diego CA, US
Qing Li - San Diego CA, US
Alexey Pronin - San Diego CA, US
Guy Servant - San Diego CA, US
Lan Zhang - San Diego CA, US
Thomas Brady - San Diego CA, US
Vincent Darmohusodo - San Diego CA, US
Melissa Arellano - San Diego CA, US
Victor Selchau - San Diego CA, US
Brett Weylan Ching - San Diego CA, US
Donald S. Karanewsky - Escondido CA, US
Paul Brust - San Diego CA, US
Jing Ling - Carlsbad CA, US
Wen Zhao - San Diego CA, US
Chad Priest - Encinitas CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

A61K 9/68
G01N 33/68
C12Q 1/02
G01N 33/53
C07D 261/06
C07C 65/00
C07D 307/02
C07D 413/02
A61K 31/192
A61K 31/7034
A61K 31/4439
A61K 31/55
C07K 14/435
C07D 241/36
C07D 263/54
C07D 213/62
C07D 223/18
C07D 239/72
C07D 487/02
C07D 413/14
C07D 403/14
C07D 233/00
C07D 249/12
C07D 251/02
A61K 31/4164
A61K 31/4196
A61K 31/53
A61K 31/42
A61K 8/49
A61P 27/00
A61Q 11/00

US Classification:

424 48, 436 86, 435 29, 436501, 548247, 562426, 549491, 5462721, 514562, 514 35, 514338, 514216, 435 72, 530402, 544356, 548217, 546300, 540587, 544354, 544285, 544256, 544118, 540600, 5483167, 5482634, 544180, 514386, 514384, 514241, 514378, 424 49

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

US Patent:

20130183252, Jul 18, 2013

Filed:

Feb 10, 2012

Appl. No.:

13/370832

Inventors:

Xiaodong LI - San Diego CA, US
Andrew Patron - San Marcos CA, US
Catherine Tachdjian - San Diego CA, US
Hong Xu - San Diego CA, US
Qing Li - Draper UT, US
Alexey Pronin - San Diego CA, US
Guy Servant - San Diego CA, US
Lan Zhang - San Diego CA, US
Thomas Brady - San Diego CA, US
Vincent Darmohusodo - Encinitas CA, US
Melissa Arellano - San Diego CA, US
Victor Selchau - San Diego CA, US
Brett Weylan Ching - San Diego CA, US
Donald S. Karanewsky - Escondido CA, US
Paul Brust - San Diego CA, US
Jing Ling - Carlsbad CA, US
Wen Zhao - San Diego CA, US
Chad Priest - Encinitas CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

C07C 311/17
C07D 223/18
A61K 8/46
A61Q 11/00
C07D 213/71
C07D 333/34
C07D 317/58
A61K 8/49
C07C 311/16
C07C 311/19
C07C 311/46
C07C 311/18
C07C 233/73
C07D 333/20
C07D 213/42
C07D 217/08
A23L 1/22
C07D 307/52

US Classification:

424 48, 562430, 549494, 540587, 514784, 424 54, 546293, 549 65, 549444, 548252, 558413, 562451, 549 77, 546335, 546141, 514785, 514788, 426535, 426537, 426538

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

US Patent:

20210309654, Oct 7, 2021

Filed:

Aug 6, 2019

Appl. No.:

17/266074

Inventors:

- Plainsboro NJ, US
Catherine Tachdjian - San Diego CA, US
Guy Servant - San Diego CA, US
Brett Weylan Ching - San Diego CA, US
Timothy Davis - Santee CA, US

International Classification:

C07D 417/14
C07D 417/12
A23L 27/00
A23L 27/20
A23L 27/30
A23L 2/60
A23L 2/56

Abstract:

Disclosed herein are 5-Substituted 4-amino-1H-benzo[c] [1,2,6]thiadiazine 2,2-dioxide compounds useful as sweet flavor modifiers. Also disclosed herein are ingestible compositions that include one or more of these compounds in combination with a natural or artificial sweetener.

US Patent:

20160185727, Jun 30, 2016

Filed:

Oct 28, 2015

Appl. No.:

14/925793

Inventors:

- San Diego CA, US
Joseph R. Fotsing - San Diego CA, US
Guy Servant - San Diego CA, US
Catherine Tachdjian - San Diego CA, US
Donald Karanewsky - Escondido CA, US
Binh Vong - San Diego CA, US
Brant Clayton Boren - San Diego CA, US
Qing Chen - San Diego CA, US
Hong Zhang - San Diego CA, US
Brett Weylan Ching - San Diego CA, US
Stephanie Lapera - San Diego CA, US

International Classification:

C07D 215/54
A23L 2/60
A23L 2/56
C07D 405/12
C07D 401/12

Abstract:

Disclosed herein are 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acid compounds having useful as sweet flavor modifiers. Also disclosed herein are ingestible compositions that include one or more of these compounds in combination with a natural or artificial sweetener.