Bradley M Christenson

US Patent:

7056534, Jun 6, 2006

Filed:

Aug 19, 2004

Appl. No.:

10/921789

Inventors:

Bradley L. Christenson - Blaine MN, US
Phillip W. Dritsas - Shorewood MN, US

Assignee:

Upsher-Smith Laboratories, Inc. - Maple Grove MN

International Classification:

A61K 9/16

US Classification:

424490, 424464, 424474, 424489, 424494

Abstract:

This invention provides extended release potassium chloride granules consisting essentially of potassium chloride crystals having a mesh size of about 20–60 mesh that are coated only with ethylcellulose. The granules may be compressed into tablets that disintegrate rapidly in an aqueous environment to provide uniform dissolution of the potassium chloride. Tablets containing about 10 to about 20 milliequivalents potassium may be formulated in accordance with the invention. Processes to produce extended release granules without using surfactants, processing aids or other coating aids are also provided by this invention. A method is further provided whereby a patient's supplemental potassium requirements are met by administering an appropriate combination of dosage units chosen from available dosage units containing different quantities of potassium.

US Patent:

20030104070, Jun 5, 2003

Filed:

Oct 23, 2001

Appl. No.:

10/040070

Inventors:

Bradley Christenson - Blaine MN, US
Mark Pieloch - Lincoln NE, US

International Classification:

A61K033/14
A61K009/16
A61K009/50

US Classification:

424/495000, 424/679000

Abstract:

This invention provides extended release potassium chloride granules consisting essentially of potassium chloride crystals having a mesh size of about 20-60 mesh that are coated only with ethylcellulose. The granules may be compressed into tablets that disintegrate rapidly in an aqueous environment to provide uniform dissolution of the potassium chloride. Processes to produce extended release granules without using surfactants, processing aids or other coating aids are also provided by this invention.

US Patent:

20030104071, Jun 5, 2003

Filed:

Feb 14, 2002

Appl. No.:

10/076892

Inventors:

Bradley Christenson - Blaine MN, US
Mark Pieloch - Lincoln NE, US

International Classification:

A61K033/14
A61K009/16
A61K009/50

US Classification:

424/495000, 424/679000

Abstract:

This invention provides extended release potassium chloride granules consisting essentially of potassium chloride crystals having a mesh size of about 20-60 mesh that are coated only with ethylcellulose. The granules may be compressed into tablets that disintegrate rapidly in an aqueous environment to provide uniform dissolution of the potassium chloride. Tablets containing about 10 to about 20 milliequivalents potassium may be formulated in accordance with the invention. Processes to produce extended release granules without using surfactants, processing aids or other coating aids are also provided by this invention. A method is further provided whereby a patient's supplemental potassium requirements are met by administering an appropriate combination of dosage units chosen from available dosage units containing different quantities of potassium.