Bradley R Cairns

US Patent:

20110318738, Dec 29, 2011

Filed:

Dec 4, 2009

Appl. No.:

13/141432

Inventors:

David Jones - Salt Lake City UT, US
Bradley Cairns - Salt Lake City UT, US
Kunal Rai - Salt Lake City UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

C12Q 1/68

US Classification:

435 611, 435 612

Abstract:

Disclosed herein are methods and systems directed at detecting, evaluating, ameliorating, preventing and treating an oncogenic event. The disclosed methods and systems can comprise one or more Demethylase System Components or other compositions that can be used alone or in combination to detect, evaluate, treat, ameliorate, or prevent an oncogenic event.

US Patent:

20200087629, Mar 19, 2020

Filed:

Oct 19, 2017

Appl. No.:

16/342856

Inventors:

- Seattle WA, US
- Salt Lake City UT, US
Peter G HENDRICKSON - Salt Lake City UT, US
Edward J GROW - Salt Lake City UT, US
Bradley R CAIRNS - Salt Lake City UT, US

International Classification:

C12N 5/074
A61K 35/28
C12N 15/90
C12N 5/0735
C12N 5/073

Abstract:

It was found that DUXC family proteins were efficient activators of EGA and that DUXC proteins could be used in methods in the reprogramming of cells to a totipotent state and to increase the efficiency of somatic cell nuclear transfer (SCNT). Accordingly, aspects of the disclosure relate to a method for reprogramming a cell into a totipotent state, the method comprising expressing a DUXC family protein in the cell. Further aspects of the disclosure relate to a method for making a host cell nuclear transfer (SCNT) embryo comprising expressing a DUXC protein in a somatic cell and transferring the nucleus of the somatic cell to an enucleated oocyte, thereby making a SCNT embryo.

US Patent:

20190048418, Feb 14, 2019

Filed:

Mar 5, 2018

Appl. No.:

15/912231

Inventors:

- Salt Lake City UT, US
Bradley R. Cairns - Salt Lake City UT, US
Timothy G. Jenkins - Salt Lake City UT, US
Kenneth I. Aston - Salt Lake City UT, US

International Classification:

C12Q 1/6883
G06F 19/18

Abstract:

Methods, systems, and diagnostic tests, including test kits for assessing an offspring's risk of developing a disease or condition known or suspected to have a causal or contributing relationship to an age related epigenetic event in a paternal germ line are disclosed and described.

US Patent:

20160208327, Jul 21, 2016

Filed:

Aug 21, 2014

Appl. No.:

14/913246

Inventors:

Douglas T. CARRELL - Salt Lake City UT, US
Bradley R. CAIRNS - Salt Lake City UT, US
Timothy G. JENKINS - Salt Lake City UT, US
Kenneth I. ASTON - Salt Lake City UT, US

International Classification:

C12Q 1/68

Abstract:

Methods, systems, and diagnostic tests, including test kits for assessing an offspring's risk of developing a disease or condition known or suspected to have a causal or contributing relationship to an age related epigenetic event in a paternal germ line are disclosed and described