Bonnie L Hurwitz

US Patent:

20070087345, Apr 19, 2007

Filed:

Jul 9, 2004

Appl. No.:

10/564136

Inventors:

Michelle Curtis - Cottage Grove WI, US
Kyle Armantrout - Los Angeles CA, US
Feng Cao - Milwaukee WI, US
Bonnie Hurwitz - Madison WI, US
Daniel Machmeier - Middleton WI, US
Sara Olson - Cross Plains WI, US
Hon Ip - Madison WI, US
Robert Kwiatkowski Jr - Verona WI, US
LuAnne Chehak - Janesville WI, US

Assignee:

THIRD WAVE TECHNOLOGIES, INC. - Madison WI

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The present invention relates to compositions, methods, and kits for quantifying variations in gene copy number, e.g., of individual genes or of chromosomes or portions of chromosomes in an homogeneous reaction, without the need for target amplification, fragment size resolution, or microscopy.

US Patent:

20170058430, Mar 2, 2017

Filed:

Feb 18, 2015

Appl. No.:

15/119745

Inventors:

- Tucson AZ, US
Bonnie L. Hurwitz - Tucson AZ, US

International Classification:

C40B 30/02
C12Q 1/68
C12Q 1/04

Abstract:

Disclosed herein are methods of identifying infections, such as methods of identifying bacterial infections which utilize whole metagenome sequence analysis to sequence the entire wound microbiome of clinical samples. The disclosed methods use fast k-mer based sequence analysis, predictive modeling, and Bayesian network analysis, to analyze bacterial metagenomic sequence compositions in conjunction with clinical factors to stratify communities of bacteria into healing versus non-healing clusters. The methods of identifying infections can include performing molecular analysis of a patient wound sample, preparing the data obtained from the molecular analysis, diagnosing the wound sample and/or prognosing the wound sample. The disclosed methods can also be used to identify protein function as well as novel biomarkers.