Bob S Carter

Author:

Bob Carter

ISBN #:

0710096240

Author:

Bob Carter

ISBN #:

0715805746

Author:

Bob Carter

ISBN #:

0715806424

Author:

Bob Carter

ISBN #:

0826455190

Author:

Bob Carter

ISBN #:

0826455204

US Patent:

20100105136, Apr 29, 2010

Filed:

Oct 9, 2007

Appl. No.:

12/444090

Inventors:

Bob S. Carter - Belmont MA, US
Richard C. Mulligan - Cambridge MA, US
Szofia Bullain - Brookline MA, US

Assignee:

The General Hospital Corporation - Boston MA
Children's Medical Center Corporation - Boston MA

International Classification:

C12N 5/0783
C07H 21/04
C07K 14/725

US Classification:

4353723, 536 235, 530350

Abstract:

Chimeric T-cell receptor proteins have been produced in cells by the construction of nucleic acids and vectors, and the transfection of the vectors into cells. The chimeric proteins comprise, as an extracellular binding portion, a single chain antibody portion that binds to EGFRvIII, a transmembrane portion derived from human CD8α or CD28, and an intracellular signaling portion derived from human CD3ζ. The invention includes nucleic acids, vectors and cells associated with the production of the chimeric membrane protein, as well as methods to treat rumors bearing EGFRvIII, a mutant epidermal growth factor receptor.

US Patent:

20130040833, Feb 14, 2013

Filed:

Sep 9, 2010

Appl. No.:

13/395284

Inventors:

Mikkel Noerholm - Gauting, DE
Johan Karl Olov Skog - New York NY, US
Xandra O. Breakefield - Newton MA, US
Bob Carter - San Diego CA, US

Assignee:

THE GENERAL HOSPITAL CORPORATION - Boston MA

International Classification:

C40B 30/04
C40B 40/06

US Classification:

506 9, 506 16

Abstract:

The invention concerns gene signatures obtained from microvesicles and a method of applying these gene signatures in helping to determine a biological condition. The determination of a biological condition may aid, for example, the diagnosis, prognosis, and therapy treatment selection for a disease in a subject.

US Patent:

20230027906, Jan 26, 2023

Filed:

Dec 7, 2020

Appl. No.:

17/781423

Inventors:

- Boston MA, US
Koushik Muralidharan - Boston MA, US
Anudeep Yekula - Boston MA, US
Bob S. Carter - Boston MA, US

International Classification:

C12Q 1/6886

Abstract:

Aspects of the present disclosure relate to methods for detecting mutant TERT promoter sequences (e.g., C228T, C250T) that provide several improvements over conventional detection methods, thereby enabling detection of such mutations in biological fluid samples (e.g., plasma), which contain miniscule amounts of nucleic acids. Such improvements include, but are not limited to, improvements in detection sensitivity and specificity, which allows detection of mutations in a biological sample having a low level of nucleic acids such as a plasma sample from a patient having brain cancer (e.g., glioma).

US Patent:

20200017920, Jan 16, 2020

Filed:

Jul 23, 2019

Appl. No.:

16/520130

Inventors:

- BOSTON MA, US
Johan Karl Olov SKOG - Lincoln MA, US
Xandra O. BREAKEFIELD - Newton MA, US
Bob Carter - San Diego CA, US

Assignee:

THE GENERAL HOSPITAL CORPORATION - BOSTON MA

International Classification:

C12Q 1/6886
C12Q 1/6806
G01N 33/574

Abstract:

The invention concerns gene signatures obtained from microvesicles and a method of applying these gene signatures in helping to determine a biological condition. The determination of a biological condition may aid, for example, the diagnosis, prognosis, and therapy treatment selection for disease in a subject.

US Patent:

20170147908, May 25, 2017

Filed:

Jul 7, 2015

Appl. No.:

15/323530

Inventors:

- Oakland CA, US
Tyler STEED - San Diego CA, US
Bob S. CARTER - San Diego CA, US
Anders M. DALE - La Jolla CA, US

International Classification:

G06K 9/62
G06T 7/187
G06T 7/11
G01R 33/56
G06T 7/00

Abstract:

Techniques, systems, and devices are described for implementing automatic segmentation and quantitative parameterization of MRI images. For example, the disclosed method includes processing the MRI image to correct any distortions; performing a preliminary segmentation of the MRI image to assign a tissue label of a set of tissue labels to one or more preliminary volumes of voxels of the MRI image; comparing each voxel of the MRI image with the one or more preliminary volumes of voxels with an assigned tissue label and assigning each voxel of the MRI image a probability of being associated with each tissue label of the set of tissue labels; and assigning each voxel of the MRI image a tissue label according to its greatest probability among probabilities for each voxel being associated with the set of tissue labels.

US Patent:

20160002736, Jan 7, 2016

Filed:

Jul 6, 2015

Appl. No.:

14/792212

Inventors:

- BOSTON MA, US
Johan Karl Olov SKOG - New York NY, US
Xandra O. BREAKEFIELD - Newton MA, US
Bob CARTER - San Diego CA, US

Assignee:

THE GENERAL HOSPITAL CORPORATION - BOSTON MA

International Classification:

C12Q 1/68

Abstract:

The invention concerns gene signatures obtained from microvesicles and a method of applying these gene signatures in helping to determine a biological condition. The determination of a biological condition may aid, for example, the diagnosis, prognosis, and therapy treatment selection for disease in a subject.