Bo Ning

US Patent:

20100104571, Apr 29, 2010

Filed:

Dec 14, 2009

Appl. No.:

12/653443

Inventors:

Randall M. Goldblum - Dickinson TX, US
Bo Ning - Galveston TX, US
Ruby Tiwari - Palmerston North, NZ

International Classification:

A61K 39/395
C07K 16/00
A61P 37/08

US Classification:

4241331, 5303881, 4241411, 5303873

Abstract:

The present invention is drawn to antibody-mediated modulation of allergy. In this regard, the present invention discloses a monoclonal antibody, antigen-binding fragment or mimic thereof directed against Group 1 pollen allergens or homologues thereof. Also disclosed herein is the mechanism by which the disclosed monoclonal antibody, antigen binding fragment or mimic thereof will improve immunotherapy of allergic reactions in an individual. It is contemplated that herein that such a monoclonal antibody, antigen binding fragment or mimic thereof may also be useful in treatment of several microbial infections.