Bo Guan

US Patent:

20020012968, Jan 31, 2002

Filed:

Mar 20, 2001

Appl. No.:

09/813329

Inventors:

Pamela Carroll - Princeton NJ, US
Jian Chen - Princeton NJ, US
Chandra Ramanathan - Wallingford CT, US
Hong Xiao - Princeton Junction NJ, US
Bo Guan - Princeton NJ, US
Michael Bowen - Lawrenceville NJ, US

International Classification:

G01N033/53
A01K067/033
C12P021/02
C12N005/06
C07K014/52

US Classification:

435/069500, 435/348000, 530/351000, 800/013000, 435/007100

Abstract:

The present invention provides novel polynucleotides encoding Drosophila DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.

US Patent:

20050227283, Oct 13, 2005

Filed:

Jun 1, 2005

Appl. No.:

11/142736

Inventors:

Pamela Carroll - Princeton NJ, US
Jian Chen - Princeton NJ, US
Chandra Ramanathan - Wallingford CT, US
Hong Xiao - Princeton Junction NJ, US
Bo Guan - Princeton NJ, US
Michael Bowen - Lawrenceville NJ, US

International Classification:

C12Q001/68
C07H021/04
C12N015/09
C07K014/525

US Classification:

435006000, 435069500, 435348000, 435320100, 530351000, 536023500

Abstract:

The present invention provides novel polynucleotides encoding DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.

US Patent:

20060147974, Jul 6, 2006

Filed:

Feb 1, 2006

Appl. No.:

11/345126

Inventors:

Pamela Carroll - Princeton NJ, US
Jian Chen - Princeton NJ, US
Chandra Ramanathan - Wallingford CT, US
Hong Xiao - Princeton Junction NJ, US
Bo Guan - Princeton NJ, US
Michael Bowen - Lawrenceville NJ, US

International Classification:

C12Q 1/68
C07H 21/04
C12P 21/02
C07K 14/525
C12N 5/06

US Classification:

435006000, 435069500, 435320100, 435348000, 530351000, 536023500

Abstract:

The present invention provides novel polynucleotides encoding DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.