Medical School Ohio State University / College of Medicine Graduated: 1992 Medical School Oh State U Graduated: 1992 Medical School U Of Washington Graduated: 1992
Blythe Thomson, Seattle WA
Work:
Seattle Children's Hospital
4800 Sand Point Way NE, Seattle, WA 98105
Name / Title
Company / Classification
Phones & Addresses
Blythe Thomson Doctor Of Medicine
Childrens Hospital and Regional Medical Center Medical Laboratories
4800 Sand Point Way Ne Stop 6D-1, Seattle, WA 98105
Blythe Thomson Doctor Of Medicine
Children's Hospital And Regional Medical Center Medical Laboratories · Specialty (except Psychiatric and Substance Abuse) Hospitals
4800 Sand Pt Way NE, Seattle, WA 98105 6901 Sand Pt Way NE, Seattle, WA 98115 206 987-2000, 206 987-2253, 206 987-1426
- Watertown MA, US Susan Ashwell - Carlisle MA, US Blythe Thomson - Cincinnati OH, US Alan Collis - Lexington MA, US Jeff Davis - Hingham MA, US Duncan Walker - Boulder CO, US Wei Lu - Newton MA, US
International Classification:
A61K 31/4709 A61P 35/00
Abstract:
Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.
- Watertown MA, US Blythe THOMSON - Cincinnati OH, US Patrick F. KELLY - Concord MA, US Alan COLLIS - Lexington MA, US Jeff DAVIS - Hingham MA, US Duncan WALKER - Boulder CO, US Wei LU - Newton MA, US
International Classification:
A61K 31/4709 A61K 31/706 A61P 35/00 A61P 35/02
Abstract:
Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.
Treating Patients Harboring An Isocitrate Dehydrogenase 1 (Idh-1) Mutation
- Watertown MA, US Alan Collis - Lexington MA, US Jeff Davis - Hingham MA, US Duncan Walker - Boulder CO, US Susan Ashwell - Carlisle MA, US Blythe Thomson - Cincinnati OH, US Wei Lu - Newton MA, US
International Classification:
A61K 31/4709 A61P 35/02 C12Q 1/686 C12Q 1/6886
Abstract:
Methods of treating patients diagnosed with AML or MDS harboring mutant IDH-1 include detecting an IDH1 mutation and the therapeutic administration of an inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA) or cytarabine.
- Watertown MA, US Alan Collis - Lexington MA, US Jeff Davis - Hingham MA, US Duncan Walker - Boulder CO, US Susan Ashwell - Carlisle MA, US Blythe Thomson - Newton MA, US
International Classification:
A61K 31/4709 A61P 35/00 A61K 9/00
Abstract:
Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).
Treatment Of Leukemia Via The Administration Of Dot1L Inhibitor Pinometostat
- Cambridge MA, US Scott R. DAIGLE - Newburyport MA, US Eric HEDRICK - Summit NJ, US Nigel WATERS - Belmont MA, US Blythe THOMSON - Newton MA, US
International Classification:
A61K 31/7076 A61P 35/02
Abstract:
The present invention relates to DOT1L inhibitors. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof
- Watertown MA, US Alan Collis - Lexington MA, US Jeff Davis - Hingham MA, US Duncan Walker - Boulder CO, US Susan Ashwell - Carlisle MA, US Blythe Thomson - Newton MA, US
International Classification:
A61K 31/4709 A61K 9/00 A61P 35/00
Abstract:
Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).
Treatment Of Leukemia Via The Administration Of Dot1L Inhibitor Pinometostat
- Cambridge MA, US Scott R. DAIGLE - Newburyport MA, US Eric HEDRICK - Summit NJ, US Nigel WATERS - Belmont MA, US Blythe THOMSON - Newton MA, US
International Classification:
A61K 31/7076 A61P 35/02
Abstract:
The present invention relates to a method for the treatment of leukemia and the induction of leukemic blast cell maturation or differentiation via the administration of the DOT1L inhibitor pinometostat (otherwise known as EPZ-5676; CAS Registry number 1380288-87-8) or its N-oxide or pharmaceutically acceptable salt thereof.
- Cambridge MA, US Scott R. Daigle - Newburyport MA, US Eric Hedrick - Summit NJ, US Nigel Waters - Belmont MA, US Blythe Thomson - Newton MA, US
International Classification:
A61K 31/7076
Abstract:
The present invention relates to DOT1L inhibitors. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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