Betty B Chang

US Patent:

20120148490, Jun 14, 2012

Filed:

Dec 1, 2011

Appl. No.:

13/309295

Inventors:

Benjamin H. Dutzar - Seattle WA, US
Brian R. Kovacevich - Snohomish WA, US
Patricia Dianne NcNeill - Federal Way WA, US
Danielle M. Mitchell - Seattle WA, US
Ethan W. Ojala - Snohomish WA, US
Pei Fan - Bothell WA, US
Jens Billgren - Seattle WA, US
Erica A. Stewart - Shoreline WA, US
Corinne C. Akatsuka - Hilo HI, US
Betty Yu-Ching Chang - Cupertino CA, US
John A. Latham - Seattle WA, US
Leon F. Garcia-Martinez - Woodinville WA, US

International Classification:

A61K 39/395
C12N 15/13
A61K 49/00
A61K 51/10
A61P 29/00
A61P 25/00
A61P 19/10
A61P 35/00
A61P 1/16
A61P 25/06
A61P 31/04
A61P 21/00
C12N 15/63
C12N 5/10
C12N 1/21
C12N 1/15
C12N 1/19
C12N 9/96
C12P 21/02
A61P 37/08
C07K 16/22

US Classification:

424 149, 5303892, 5303873, 5303913, 536 2353, 4241581, 424 91, 5303917, 5303911, 4353201, 435335, 4352523, 435419, 43525411, 4352542, 43525423, 424 96, 435188, 530367, 435 696, 800 6

Abstract:

The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.

US Patent:

20130336975, Dec 19, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/833338

Inventors:

Benjamin H. Dutzar - Seattle WA, US
Brian R. Kovacevich - Snohomish WA, US
Patricia Dianne McNeill - Federal Way WA, US
Danielle M. Mitchell - Seattle WA, US
Ethan W. Ojala - Snohomish WA, US
Pei Fan - Bothell WA, US
Jens Billgren - Seattle WA, US
Erica A. Stewart - Shoreline WA, US
Corinne C. Akatsuka - Hilo HI, US
Betty Yu-Ching Chang - Cupertino CA, US
John A. Latham - Seattle WA, US
Leon F. Garcia-Martinez - Woodinville WA, US

International Classification:

C07K 16/22

US Classification:

4241351, 5303892, 5303873, 5303913, 5303917, 536 2353, 4353201, 435335, 4352542, 4352523, 43525411, 435419, 4241581, 435 71, 435328

Abstract:

The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.