Bernard M Levine

Author:

Bernard R. Levine

ISBN #:

0873649745

Author:

Bernard R. Levine

ISBN #:

0930478010

Author:

Bernard Levine

ISBN #:

0814314147

Author:

Bernard Levine

ISBN #:

0873419456

Author:

Bernard Levine

ISBN #:

0873491890

US Patent:

42527848, Feb 24, 1981

Filed:

Aug 23, 1979

Appl. No.:

6/069149

Inventors:

Bernard B. Levine - New York NY

International Classification:

A61K 4900

US Classification:

424 9

Abstract:

The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicilloyl-polylysine (PPL) preparations, and novel test methods employing such materials. The new PPL preparations comprise homogeneous, high purity, maximally coupled,. alpha. -diastereoisomeric, penicilloyl conjugates of low molecular weight PPLs. The PPL materials of the invention have the molecular structure in accordance with the following generic formula: ##STR1## wherein: R is selected from the group consisting of H and penicilloyl groups or similar groups derived from cephalosporins or other. beta. -lactam antibiotics; and n is an integer of from 4 to 10, at least about 66% and up to 100% of the R groups are other than hydrogen. Solutions containing this PPL material are useful in skin testing for penicillin allergy or hypersensitivity alone, but preferably are utilized in a two-part test with MDM solutions containing the novel MDM materials of the invention.

US Patent:

42281474, Oct 14, 1980

Filed:

May 9, 1979

Appl. No.:

6/037248

Inventors:

Bernard B. Levine - New York NY

International Classification:

A61K 2900
A61K 3143

US Classification:

424 9

Abstract:

The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicilloyl-polylysine (PPL) preparations, new materials for use in minor determinant mixture (MDM) compositions and novel test methods employing such materials. The new PPL preparations comprise homogeneous, high purity, maximally coupled,. alpha. -diastereoisomeric, penicilloyl conjugates of low molecular weight PPLs. The PPL materials of the invention have the molecular structure in accordance with the following generic formula: ##STR1## wherein: R is selected from the group consisting of H and penicilloyl groups or similar groups derived from cephaolosporins or other. beta. -lactam antibiotics; and n is an integer of from 4 to 10, at least about 66% and up to 100% of the R groups are other than hydrogen. Solutions containing this PPL material are useful in skin testing for penicillin allergy or hypersensitivity alone, but preferably are utilized in a two-part test with MDM solutions containing the novel MDM materials of the invention.

US Patent:

43168825, Feb 23, 1982

Filed:

Aug 30, 1979

Appl. No.:

6/071418

Inventors:

Bernard B. Levine - New York NY

International Classification:

A61K 4900

US Classification:

424 9

Abstract:

The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new materials for use in minor determinant mixture (MDM) compositions and lyophilized, storage-stable MDM compositions and novel test methods employing such materials. The new MDM materials are N-penicilloyl amines of an aliphatic amine or. alpha. -aminoacid having the following molecular structure: ##STR1## wherein: R. sub. 1 =a side chain which defines the type of penicillin--e. g. , where R. sub. 1 = ##STR2## the new material is a derivative of benzylpenicillin; and R. sub. 2 is an alkyl group of C. sub. 2 -C. sub. 6 length, preferably ethyl or propyl, or an aminoacid residue as described herein.

US Patent:

41839102, Jan 15, 1980

Filed:

Apr 20, 1978

Appl. No.:

5/898044

Inventors:

Bernard B. Levine - New York NY

International Classification:

C07D27706
C07D41712
A61K 3702
A61K 31425

US Classification:

424 9

Abstract:

The invention relates to the testing of humans or other animals, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicilloyl-polylysine (PPL) preparations, new materials for use in minor determinant mixture (MDM) compositions and novel test methods employing such materials. The new PPL preparations comprise homogeneous, high purity, maximally coupled,. alpha. -diastereoisomeric, penicilloyl conjugates of low molecular weight PPLs. The PPL materials of the invention have the molecular structure in accordance with the following generic formula: ##STR1## wherein: R is selected from the group consisting of H and penicilloyl groups or similar groups derived from cephalosporins or other. beta. -lactam antibiotics; and n is an integer of from 4 to 10, at least about 66% and up to 100% of the R groups are other than hydrogen. Solutions containing this PPL material are useful in skin testing for penicillin allergy or hypersensitivity alone, but preferably are utilized in a two-part test with MDM solutions containing the novel MDM materials of the invention.