Benjamin P Fauber

US Patent:

8293927, Oct 23, 2012

Filed:

May 12, 2010

Appl. No.:

12/778466

Inventors:

Philip D. Magnus - Austin TX, US
Benjamin P. Fauber - San Francisco CA, US
Neeraj Sane - Pune, IN

Assignee:

Board of Regents the University of Texas System - Austin TX

International Classification:

C07D 307/94

US Classification:

549345

Abstract:

The present invention relates to methods for the synthesis of morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

US Patent:

8362283, Jan 29, 2013

Filed:

May 12, 2010

Appl. No.:

12/778392

Inventors:

Philip D. Magnus - Austin TX, US
Benjamin P. Fauber - San Francisco CA, US
Neeraj Sane - Pune, IN

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 317/70
C07D 307/94

US Classification:

549345, 549432, 544 69

Abstract:

The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

US Patent:

20100292466, Nov 18, 2010

Filed:

May 12, 2010

Appl. No.:

12/778515

Inventors:

Philip D. Magnus - Austin TX, US
Benjamin P. Fauber - San Francisco CA, US
Neeraj Sane - Pune, IN

International Classification:

C07D 223/14
C07D 311/78

US Classification:

540576, 549383

Abstract:

The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

US Patent:

20100311748, Dec 9, 2010

Filed:

Aug 29, 2008

Appl. No.:

12/675728

Inventors:

Leslie Dakin - Waltham MA, US
Benjamin Fauber - Waltham MA, US
Alexander Hird - Waltham MA, US
James Janetka - Waltham MA, US
Daniel John Russell - Waltham MA, US
Qibin Su - Waltham MA, US
Bin Yang - Waltham MA, US
Xiaolan Zheng - Waltham MA, US

Assignee:

ASTRAZENECA AB - Sodertalje

International Classification:

A61K 31/5377
C07D 401/12
A61K 31/4439
C07D 417/14
A61K 31/496
C07D 513/04
A61K 31/444
A61K 31/497
A61K 31/501
C07D 233/64
A61K 31/4164
A61P 35/00

US Classification:

5142358, 5462727, 514341, 544364, 5142531, 5462734, 5462701, 514338, 546261, 514335, 544405, 51425505, 544131, 544238, 5142368, 51425203, 5483435, 514400

Abstract:

The present disclosure relates to heterocyclic amide compounds, which are useful for inhibiting the Hedgehog pathway, and their use in treating a disease or medical condition mediated alone or in part by Hedgehog pathway inhibition. Also disclosed are methods for manufacture of these compounds, pharmaceutical compositions including these compounds, and use of these compounds in the manufacture of medicaments for treating such diseases and medical conditions in a subject. Formula (IA) with the provisio that either Ror Ris (Z).

US Patent:

20140031330, Jan 30, 2014

Filed:

Jul 11, 2013

Appl. No.:

13/939962

Inventors:

Benjamin Fauber - San Francisco CA, US
Simon Gaines - Harlow, Essex, UK
Alberto Gobbi - San Francisco CA, US
Olivier Rene - San Francisco CA, US
David Vesey - Harlow, Essex, UK
Stuart Ward - Harlow, Essex, UK

International Classification:

C07D 487/04
C07D 417/12
C07D 471/04
C07D 295/185

US Classification:

5142102, 544 3, 5142222, 544367, 51425404, 540544, 51421115, 540575, 514218

Abstract:

Compounds of the formula I:or pharmaceutically acceptable salts thereof,wherein m, n, p, q, r, A, W, X, X, X, X, Y, Z, R, R, R, R, R, R, R, R, R, R, R, and Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

US Patent:

20210294850, Sep 23, 2021

Filed:

Mar 23, 2020

Appl. No.:

16/826562

Inventors:

- Round Rock TX, US
Benjamin Fauber - Austin TX, US

International Classification:

G06F 16/906
G06Q 50/26
G06F 16/901
G06F 16/903
G06F 21/62

Abstract:

An apparatus includes a processing device configured to obtain first and second sets of data records, each data record comprising a string associated with an attribute. The processing device is also configured to generate a similarity matrix, wherein entries of the similarity matrix comprise values characterizing similarity between respective pairs of the strings comprising a first string from a data record in the first set and a second string from a data record in the second set. The processing device is further configured to construct a graph network based on the similarity matrix comprising edges connecting pairs of the data records based on values of entries in the similarity matrix, perform a clustering operation on the graph network to identify clusters, and to initiate remedial action responsive to identifying a given cluster comprising at least one data record from each of the first and second sets of data records.

US Patent:

20190263794, Aug 29, 2019

Filed:

Apr 30, 2019

Appl. No.:

16/398795

Inventors:

- South San Francisco CA, US
James J. Crawford - South San Francisco CA, US
Andrew Cridland - Essex, GB
Patrick Cyr - Saint Constant, CA
Benjamin Fauber - Austin TX, US
Emanuela Gancia - Essex, GB
Alberto Gobbi - South San Francisco CA, US
Christopher Hurley - Essex, GB
Jonathan Killen - Essex, GB
Wendy Lee - South San Francisco CA, US
Olivier Rene - South San Francisco CA, US
Monique Bodil Van Niel - Essex, GB
Stuart Ward - Essex, GB
Paul Winship - Essex, GB
Jason Zbieg - South San Francisco CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07D 413/14
C07D 403/14
C07D 405/14

Abstract:

Compounds of formula I:or pharmaceutical salts thereof,wherein m, n, p, q A, B, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

US Patent:

20180263996, Sep 20, 2018

Filed:

Dec 19, 2017

Appl. No.:

15/847400

Inventors:

- South San Francisco CA, US
Benjamin FAUBER - Austin TX, US
David VESEY - Essex, GB
Paul WINSHIP - Essex, GB
Tammy LADDUWAHETTY - Essex, GB

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 31/541
A61P 19/02
A61P 11/06
A61P 17/06
A61P 37/02
A61P 29/00

Abstract:

Compounds of the formula I: