Bard J Geesaman

US Patent:

20050256181, Nov 17, 2005

Filed:

Jan 31, 2005

Appl. No.:

11/047757

Inventors:

Peter Distefano - Southboro MA, US
Alan Watson - Lexington MA, US
Rory Curtis - Ashland MA, US
Bard Geesaman - Cambridge MA, US
L. Cannon - Cambridge MA, US
Manuel Navia - Lexington MA, US

International Classification:

A61K031/403

US Classification:

514411000

Abstract:

Heterocyclic compounds of formula (I) and methods of treating or preventing an HIV-mediated disorder by administering a compound of formula (I) are described herein.

US Patent:

20050261332, Nov 24, 2005

Filed:

Apr 4, 2005

Appl. No.:

11/098315

Inventors:

Peter Distefano - Southboro MA, US
Andrew Napper - Salem MA, US
Rory Curtis - Ashland MA, US
Jay Luly - Wellesley MA, US
Jean-Francois Pons - Abingdon, GB
Russell Thomas - Siena, IT
Manuel Navia - Lexington MA, US
Thomas Coulter - Oxforshire, GB
Jeffrey Saunders - Acton MA, US
Bard Geesaman - Cambridge MA, US

International Classification:

C07D471/02
C07D413/02
C07D043/02
A61K031/4745
A61K031/454
A61K031/4245
A61K031/422

US Classification:

514300000, 514374000, 514364000, 514381000, 514326000, 514397000, 514406000, 546118000, 548253000, 546209000, 546210000, 548133000, 548215000, 548311100, 548266200

Abstract:

Compounds of formulas (I), (II), (III), and (IV) and methods of treating disorders by administering a compound of formula (I), (II), (III), or (IV) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.

US Patent:

20060019952, Jan 26, 2006

Filed:

Jan 31, 2005

Appl. No.:

11/048490

Inventors:

Peter Distefano - Southboro MA, US
Alan Watson - Lexington MA, US
Rory Curtis - Ashland MA, US
Bard Geesaman - Cambridge MA, US
L. Cannon - Cambridge MA, US
Manuel Navia - Lexington MA, US

International Classification:

A61K 31/5377
A61K 31/519
A61K 31/381
A61K 31/40

US Classification:

514235500, 514260100, 514447000, 514426000

Abstract:

Heterocyclic compounds of formula (I), (II), (III), and (IV) and methods of treating or preventing an HIV-mediated disorder by administering a compound of formula (I), (II), (III), or (IV) are described herein.

US Patent:

20070105109, May 10, 2007

Filed:

Jul 1, 2004

Appl. No.:

10/562389

Inventors:

Bard Geesaman - Cambridge MA, US
Laura Brass - Cambridge MA, US

International Classification:

C12Q 1/68
G06F 19/00

US Classification:

435006000, 702020000

Abstract:

Alzheimer's Disease (AD) is genetically linked to a locus that includes the SIRT1 gene. This disclosure includes methods and compositions for evaluating genetic variances, e.g., within this locus, and for the association of these variances with AD. The disclosure also includes methods and compositions for modulating SIRT1 expression and/or activity. These methods and compositions can be used in the prevention or treatment of AD.

US Patent:

20070167525, Jul 19, 2007

Filed:

Nov 7, 2006

Appl. No.:

11/557377

Inventors:

BARD GEESAMAN - Waltham MA, US

International Classification:

A61K 31/155

US Classification:

514635000

Abstract:

Methods of treating glucose related disorders, for example by administering a meglitinide such as mitiglinide, repaglinide, or nateglinide, optionally in combination with a biguanide such as metformin, are described herein.

US Patent:

20080261873, Oct 23, 2008

Filed:

Aug 18, 2005

Appl. No.:

11/573841

Inventors:

Bard J. Geesaman - Waltham MA, US

Assignee:

ELIXIR PHARMACEUTICALS, INC. - Cambridge MA

International Classification:

A61K 38/22
A61K 31/438
A61K 31/404
A61K 31/165
A61K 31/437
A61K 31/4025
A61K 31/7048
A61P 1/00
A61K 31/569
A61K 38/30
A61K 31/4168
A61K 31/407
A61K 31/4412

US Classification:

514 12, 514278, 514418, 514616, 514303, 514422, 514 29, 514325, 514171, 514401, 514415, 514411, 514351

Abstract:

Disclosed are methods of treating a disorder of the stomach, intestine or duodenum in a human subject. The method includes administering to the subject, a pharmaceutical composition comprising a compound that increases gastrointestinal motility (e.g., by modulating myenteric nerve activity) and/or induces the secretion or production of growth hormone.

US Patent:

20090221652, Sep 3, 2009

Filed:

Nov 7, 2006

Appl. No.:

12/092795

Inventors:

Bard J. Geesaman - Seattle WA, US

International Classification:

A61K 31/403
A61K 31/4418
A61K 31/197
A61K 31/155
A61P 3/10

US Classification:

514357, 514412, 514563, 514635

Abstract:

Methods of treating glucose related disorders, for example by administering a meglitinide such as mitiglinide, repaglinide, or nateglinide, optionally in combination with a biguanide such as metformin, are described herein.

US Patent:

20040175700, Sep 9, 2004

Filed:

Mar 3, 2003

Appl. No.:

10/378397

Inventors:

Bard Geesaman - Cambridge MA, US

Assignee:

ELIXIR PHARMACEUTICALS, INC.

International Classification:

C12Q001/68
G01N033/53
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 435/007100, 702/019000, 702/020000

Abstract:

Information for each individual of a first group of individuals and each individual of a second group of individuals is used to select a subset of individuals from the second group. The information can be about a plurality of different biological features. The selection can use a comparison between information for members of the first group and information for members of the subset. It is also possible to compare members of the first group to members of the selected subset with respect to at least one factor. The method can be used to reduce stratification, for example, in the analysis of genetic associations.